T1期肾透明细胞癌组织中B7-H4的表达与预后的关系  

The relationship between B7-H4 expression and prognosis of stage T1 renal cell carcinoma

作　　者：吴岩[1] 于得水[1] 李琛[1] 徐新宇[1] 施卫国[1] 程晓冬[1] 顾震华[1] 董坚[1] 丛军[1] 

机构地区：[1]南京医科大学附属无锡第二人民医院泌尿外科,江苏无锡214002

出　　处：《南京医科大学学报（自然科学版）》2012年第6期816-818,822,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:研究B7-H4在T1期肾癌组织中的表达及其评估预后的价值。方法:检测并统计102例肾癌标本中B7-H4的表达率、肾癌患者临床特征及术后复发率等。结果:B7-H4表达阳性及阴性组在临床及病理特征方面无统计学差异;无瘤生存率和转移率方面阳性组明显高于阴性组,具有统计学差异;多变量分析中,肾癌术后复发方面,肿瘤大小、临床分期及B7-H4阳性表达具有显著相关性(P<0.05)。结论:B7-H4的表达与肾透明细胞癌的发生发展及免疫逃避密切相关,在评估肾癌患者预后方面具有一定价值。Objective： To investigate B7-H4 expression in stage T1 renal cell carcinoma and its role in evaluation of prognosis. Methods： B7-H4 expression was detected in kidney specimen from 102 cases,whose clinical features and renal cell carcinoma recur- rence rate were also recorded. Results： There was no significant difference in the clinical and pathological features between the B7- H4 positive and negative groups;the disease free survival rate and metastasis rate were significantly higher in the B7-H4 positive group than those of the negative group. Tumor size and clinical stage have a significant correlation with the B7-H4 expression in renal cell carcinoma recurrence after surgery（P 〈 0.05）. Conclusion： The B7-H4 expression is closely related to the development and immune evasion of renal clear cell carcinoma, and is valuable in predicting the prognosis of patients with renal cell carcinoma.

关 键 词：B7-H4 肾透明细胞癌 预后 

分 类 号：R786[医药卫生—口腔医学] R737.11[医药卫生—临床医学]