益生菌治疗肠易激综合征随机对照试验的系统评价  

Probiotics for the Treatment of Irritable Bowel Syndrome:A Systematic Review on Randomized Controlled Trials

作　　者：舒小闯[1] 周淑萍[1] 陈春燕[1] 王少东[1] 汪芳裕[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)消化内科.南京210002

出　　处：《中国循证医学杂志》2012年第7期840-847,共8页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价益生菌治疗肠易激综合征(IBS)的疗效。方法计算机检索PubMed、CochraneLibrary、Web of Sicence、EMbase、MD Consult、CNKI、CBM、WanFang Data中关于益生菌与安慰剂对照治疗IBS的随机对照试验。文献检索时限均从建库至2011年6月。由两名研究者按照Cochrane系统评价员手册5.0.1标准独立评价文献质量、提取资料并交叉核对后,使用RevMan 5.1软件进行Meta分析。结果共纳入20个随机对照试验,1 713例患者。Meta分析结果显示:益生菌与安慰剂相比,在改善IBS总体症状、腹痛/腹部不适、腹胀方面,两组差异均有统计学意义。结论现有证据表明,益生菌对改善IBS症状有一定疗效。但由于纳入研究的方法学质量及各研究间诊断标准、评价方法、剂量、疗程等诸多方面存在差异,上述结论还需更多设计严格的高质量RCT进一步证实。Objective To evaluate the efficacy of probiotics for treating irritable bowel syndrome （IBS）. Methods The following databases as PubMed, The Cochrane Library, Web of Science, EMbase, MD Consult, CNKI, CBM and WanFang Data were searched from the data of their establishment to June 2011 to collect the randomized controlled tri- als （RCTs） on probiotics for treating IBS. The data were extracted and cross-checked independently by two reviewers, the methodological quality of trials was evaluated with Cochrane Handbook 5.0.2 criteria, and Meta-analysis was conducted using RevMan 5.1 software. Results A total of 20 RCTs involving 1 713 patients were included. Results of meta-analyses showed that compared with the placebo, probiotics was statistically and significantly better in improving the overall symptoms, alleviating abdominal pain/discomfort and relieving abdominal distention. Conlusion Current evidence shows probiotics may play a role in improving the symptoms of IBS. Due to a lot of differences existing among the included studies in aspects of methodological quality, diagnostic criteria, evaluation methods, dosage and course of treatment, this conclusion should be further tested with more strictly-designed and high-quality RCTs.

关 键 词：益生菌 肠易激综合征 META分析 系统评价 随机对照试验 

分 类 号：R574[医药卫生—消化系统]