吲哚醌类Schiff碱及其配合物的合成与抗肿瘤活性研究  

Synthesis and study on antitumor activities of indolinedione Schiff bases and their complexes

作　　者：钟霞[1] 安平[2] 张俊清[1] 黄剑[1] 陈年根[1] 

机构地区：[1]海南医学院药学院,海南海口571199 [2]海南省食品药品监督管理局,海南海口571206

出　　处：《化学研究与应用》2012年第7期1046-1051,共6页Chemical Research and Application

基　　金：海南省自然科学基金项目(30841)资助

摘　　要：合成了两种吲哚醌类Schiff碱配体及其过渡金属Cu(Ⅱ)、Zn(Ⅱ)、Mn(Ⅱ)、Co(Ⅱ)、Ni(Ⅱ)的配合物,并用电子光谱、红外光谱、1H NMR加以表征。采用MTT比色法测定了配合物的体外抗肿瘤活性。经电子光谱、红外光谱、1H NMR所研究的结构与所预测的基本一致,并获得了L1·Zn、L2·Cu、L2·Zn、L2·Mn、L2·Co、L2·Ni等配合物的体外抗肿瘤活性测试结果。L1·Zn配合物对肺癌细胞SPCA-1、舌癌细胞Tb、胃癌细胞MGC以及白血病细胞K562的抑制作用较弱,吲哚醌单Schiff碱配体及金属Zn均可能是导致L1.Zn配合物抗肿瘤活性较弱的因素。L2的配合物对癌细胞都有一定的杀伤作用,尤其是Cu(II)的配合物,其对这几种细胞的抑制作用明显好于其他配合物。Several schiff base ligands and their transition metal Cu（Ⅱ）、Zn（Ⅱ）、Mn（Ⅱ）、Co（Ⅱ）、Ni（Ⅱ）complexes were prepared and characterized by UV-Vis,IR and 1H NMR.Antitumor activities of the complexes in vitro were studied by the method of MTT.Structures studied by UV-Vis,IR and 1H NMR were basically in accordance with our prediction.Test results of L1·Zn complex＇s antitumor activity in vitro had been acquired.Complex L1·Zn showed a weak inhibition effect on tumor cells SPCA-1,Tb,MGC and K562,potentially because of indoledione single-Schiff base ligand and metal Zn.The complexes of L2 had antitumor activity.Among the five complexes,the Cu（Ⅱ）complex had the novel highest antitumor activity.

关 键 词：SCHIFF碱 配合物 抗肿瘤活性 

分 类 号：O623.542[理学—有机化学]