锁阳化学成分的分离与鉴定  

Isolation and identification of chemical constituents from Cynomorium songaricum

作　　者：谢石安[1] 李国玉[1,2] 张珂[1] 王航宇[1,2] 谭勇[1,2] 王金辉[1,2,3] 

机构地区：[1]石河子大学药学院,新疆石河子832002 [2]教育部省部共建新疆特种植物药资源重点实验室,新疆石河子832002 [3]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2012年第7期525-528,共4页Journal of Shenyang Pharmaceutical University

基　　金：国家科技支撑计划2012(BAI30B02)资助项目;石河子大学科学技术研究发展计划(ZRKX2009ZD05)资助项目

摘　　要：目的研究中药锁阳的化学成分。方法采用开放硅胶柱色谱、Sephadex LH-20、ODS等方法分离化合物,运用现代波谱技术确定化合物的结构。结果从锁阳乙醇提取物的乙酸乙酯萃取部分分离纯化得到5个化合物,分别鉴定为4-甲基邻苯二酚(4-methylcatechol,1)、3,4-二羟基苯甲酸乙酯(3,4-dihydroxy-benzoic acid ethyl ester,2),epiphyllocoumarin(3),(-)-落叶脂素[(-)-lariciresinol,4],dihydroapigenin(5)。结论化合物1-4为首次从锁阳科植物中得到,化合物5为首次从锁阳植物中得到。Objective To study chemical constituents from Cynomorium songaricum. Methods The com- pounds were isolated by chromatography on silica gel column, Sephadex LH-20, ODS and identified by physicochemical properties and spectrascopic analysis. Results Five compounds were obtained and identified as 4-methylcatechol （ 1 ）, 3,4-dihydroxy-benzoic acid ethyl ester （ 2 ）, epiphyllocoumarin （ 3 ）, （ - ） -laricires- inol （4）, dihydroapigenin （5）. Conclusions Compounds 1,2,3 and 4 were are isolated from Cynomoriaceae for the first time, and compound 5 is isolated from Cynomorium songaricum for the first time.

关 键 词：锁阳 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学] R284[医药卫生—药学]