Notch信号通路与多发性骨髓瘤发病机制的关系  

Notch signal pathway and the pathogenesis of multiple myeloma

作　　者：刘芹芹[1] 郭冬梅[1] 滕清良[1] 

机构地区：[1]山东省泰安市中心医院血液内科,271000

出　　处：《国际肿瘤学杂志》2012年第7期544-546,560,共4页Journal of International Oncology

基　　金：山东省自然科学基金资助项目（2009ZRA09006）;山东省医药卫生科技发展计划项目（2011HW077）

摘　　要：Notch信号通路调控机体正常组织器官形态发生、细胞凋亡和增殖等生理过程，是造血微环境调节造血细胞增殖与分化的重要信号通路。多发性骨髓瘤（MM）的发生、发展与骨髓微环境密切相关，有多种信号通路参与。新近研究发现Notch信号通路参与包括MM在内的多种肿瘤的发生发展，且是影响肿瘤侵袭、耐药的关键因素，为多发性骨髓瘤治疗的新靶点。Notch signal pathway can regulate the morphogenesis, apoptosis and cellular proliferation of normal tissues and organs, which plays an important role in regulating hematopoietic cells proliferation and dif- ferentiation in bone marrow microenvironment. The occurrence and development of multiple myeloma （MM） are closely related to the bone marrow microenvironment in which many signal pathways are involved. Recent stud- ies show that Notch signal pathway promotes the development and progression of many cancers including MM, which plays key roles in tumor invasion and drug resistance. This review focus on the recent findings on Notch signal pathway in MM, and reveals that Notch signal pathway will be identified as a potential new therapeutic target in MM.

关 键 词：多发性骨髓瘤 NOTCH信号通路 

分 类 号：R733.3[医药卫生—肿瘤]