生长抑素受体显像剂99Tcm-奥曲肽的SPECT研究  

Development of study on SPECT imaging with radioisotope 99Tcm-octreotide

作　　者：刘淼[1] 刘兴党[1] 

机构地区：[1]复旦大学附属华山医院核医学科,上海200040

出　　处：《国际放射医学核医学杂志》2012年第3期138-142,共5页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：核医学SPECT在20世纪已进入分子显像时代，受体显像尤其是生长抑素受体显像更是目前核医学显像研究的热点。利用ⅢIn、123I、99Tcm、90Y等放射性核素标记生长抑素类似物奥曲肽进行生长抑素受体显像的方法，已经比较成熟，且部分已用于临床显像。该文对99Tcm标记奥曲肽的方法（直接法、间接法）、99Tcm-奥曲肽SPECT显像方法及其临床应用等作简要概述。The development of single photon emission computed tomography imaging has stepped into a molecular level since the last century. Receptor imaging has been one of hotspots in the current nuclear medicine imaging research, especially the somatostatin receptor scintigraphy. Octreotide, a frequently used somatostatin receptor in the clinic, has been labeled with lots of radioisotopes such as rain, ⅢIn、123I、99Tcm、90Y. Earlier studies have demonstrated that the direct and indirect labelling methods of 99Tcm-octreotide have been relatively mature and have a high labeling efficiency. And SPECT imaging with 99Tcm-octreotide has a high accuracy in finding somatostatin receptor-positive lesions especially gastrointestinal neuroendocrine tumors. 99Tcm-octreotide, a promising somatostatin receptor imaging agent, will be widely used for clinical imaging.

关 键 词：奥曲肽 受体 生长抑素 锝化合物 体层摄影术 发射型计算机 单光子 

分 类 号：R730.44[医药卫生—肿瘤]