咔唑及其衍生物合成方法研究进展  

Progresses in Synthetic Methods of Carbazole and Its Derivatives

作　　者：房旭彬[1,2] 房雷[1,2] 苟少华[1,2] 

机构地区：[1]东南大学药物研究中心,南京211189 [2]江苏省生物药物高技术研究重点实验室,南京211189

出　　处：《有机化学》2012年第7期1217-1231,共15页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.81001361);教育部博士点基金青年教师(Nos.20100092120046)资助项目~~

摘　　要：咔唑及其衍生物是一类重要的含氮芳杂环化合物,具有许多独特的理化性质及生物活性,分析、归纳、总结了近5年来发表的文献,选取具有代表性的实例,并按照中间体的不同将合成方法分为四类,分别讨论了咔唑及其衍生物合成方法的进展情况,对咔唑及其衍生物成环的新方法给予重点关注.Carbazole and its derivatives are a class of important nitrogen-containing heterocyclic compounds possessing various unique properties and biological activity. Herein the current progress of their synthetic strategies reported in the past 5 years is reviewed. The representative examples, which have been divided into four categories according to the usage of differ- ent key intermediates, are selected and discussed in detail. Special emphasis is put on the newly developed cyclization reac- tions which may be useful for the construction of the tricyclic backbone of carbazoles.

关 键 词：咔唑 衍生物 合成方法 研究进展 

分 类 号：O626.2[理学—有机化学]