非酒精性脂肪肝发病机制--“二次打击”学说研究进展  

Role of “two-hit” in non-alcoholic fatty liver disease

作　　者：董姝[1,2,3] 刘平[1,2,3,4] 孙明瑜[1,2,4] 

机构地区：[1]上海中医药大学附属曙光医院 [2]上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海201203 [3]上海中医药大学,上海201203 [4]上海高校中医内科学E-研究院,上海201203

出　　处：《临床肝胆病杂志》2012年第7期551-555,共5页Journal of Clinical Hepatology

基　　金：上海中医药大学首届杏林学者、上海市重点科技攻关项目(No.11DZ1971702);上海市教育委员会E-研究院建设计划项目(No.E03008);上海高校创新团队建设项目、国家中医药管理局中医肝胆病重点学科、慢性肝病虚损重点研究室和上海市中医临床重点实验室资助

摘　　要：非酒精性脂肪肝(NAFLD)是肝脏系统中一类最为普遍的肝脏疾病。近年来,随着生活水平的提高,其发病率也逐年上升。由于NAFLD发病的隐匿性,其具体的发病机制目前仍不清楚,"二次打击"学说在其中的重要地位已得到一致认可。现就NAFLD发病机制与"二次打击"相关的细胞因子、代谢以及免疫方面等因素作一综述。The manifestation of non-alcoholic fatty liver disease（NAFLD） ranges from simple steatosis to non-alcoholic steatohepatitis.The ＂two-hit＂ hypothesis of NAFLD is widely accepted as an accurate description of the underlying pathogenic mechanism.The first hit is an increased fat flux to the liver,which predisposes a patient to the second hit,in which increased mitochondrial free fatty acid oxidation promotes oxidative stress,lipoperoxidation,and increased reactive oxygen species.In this review,we discuss the roles of immune-and inflammation-related factors,such as cytokines,and metabolic factors in the ＂two-hit＂ process of NAFLD.

关 键 词：脂肪肝 二次打击 

分 类 号：R575.5[医药卫生—消化系统]