肿瘤干细胞与肿瘤转移和治疗抗性及靶向治疗  

Tumor Stem Cells Related Tumor Metastasis,Treatment Resistance and Targeted Therapy

作　　者：胡林[1] 张沂平[1] 

机构地区：[1]浙江省肿瘤医院肿瘤内科,杭州310022

出　　处：《医学综述》2012年第12期1841-1845,共5页Medical Recapitulate

基　　金：浙江省医药卫生科学研究基金计划项目(2007B025)

摘　　要：恶性肿瘤是干细胞疾病,肿瘤干细胞在恶性肿瘤的发生、发展及放疗化疗抵抗和复发转移中可能起着关键性作用。肿瘤的传统治疗方法(如化疗或放疗)只能杀死已分化成熟的肿瘤细胞,治疗后会复发。而针对肿瘤干细胞和(或)其微环境的靶向治疗有可能会消除肿瘤干细胞和根治癌症。肿瘤干细胞的靶向治疗理念,给人类恶性肿瘤的治疗带来了新策略和新希望。Malignant tumors are stem cells diseases,and tumor stem cells play a pivotal role in the process of tumorigenesis,development,chemotherapy or radiation resistance,relapse and metastasis.Conventional treatment for cancer such as chemotherapy or radiation can merely kill differentiated and mature tumor cells,tumors will relapse after therapy.However,the therapy targeted at tumor stem cells and/or their microenvironment may eliminate tumor stem cells and eradicate malignant tumor in the future.The concept of tumor stem cells targeted therapy provides an emerging strategy and rises new hopes for the treatment of human malignant tumors.

关 键 词：干细胞 肿瘤 肿瘤干细胞 靶向治疗 耐药性 

分 类 号：R73[医药卫生—肿瘤]