声动力疗法促肿瘤细胞凋亡的研究进展  

Research Progress of Apoptotic Effect of Sonodynamic Therapy on Tumor Cells

作　　者：邱建涛[1] 吕洪光[1] 

机构地区：[1]哈尔滨医科大学附属第一医院,哈尔滨150001

出　　处：《医学综述》2012年第13期2070-2072,共3页Medical Recapitulate

摘　　要：肿瘤是危害人类健康的主要疾病之一,近年来,人们发现诱导肿瘤细胞凋亡是更加理想的肿瘤治疗方法。声动力疗法是一种以超声和声敏剂的协同作用为基础的治疗肿瘤的新方法。声动力疗法能够改变细胞的膜结构,破坏细胞骨架以及改变细胞膜电位,导致线粒体膜受损和钙离子通道发生变化,并且上调Bax、细胞色素C、caspase-3、caspase-9的表达,从而促进肿瘤细胞凋亡。Tumor is one of the major diseases that endanger human health.In recent years,it was found that inducing tumor cell apoptosis is more ideal tumor treatment.Sonodynamic therapy is a promising new technique for killing tumor cells based on the synergistic interactions of ultrasound and sonosensitizers.Studies have shown that sonodynamic therapy can change the structure of the cell membrane,destroy the cytoskeleton and change the membrane potential which induce mitochondrial membrane damage and calcium channel change.It can also raise the expression of Bax,cytochrome C,caspase-3 and caspase-9,thereby promoting tumor cell apoptosis.

关 键 词：声动力疗法 肿瘤 凋亡 

分 类 号：R730.5[医药卫生—肿瘤] R445.1[医药卫生—临床医学]