Smac、XIAP、caspase-3在鼻腔鼻窦内翻性乳头状瘤中的表达及意义  

The expression and significance of Smac、XIAP、caspase-3 in nonasal inverted papilloma

作　　者：杨莉晖[1] 单春光[2] 黄红梅[1] 许秋荣[1] 赵颖[1] 孟雅静[1] 张志红[1] 

机构地区：[1]石家庄市中心医院耳鼻咽喉科,石家庄050011 [2]河北医科大学第二医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第14期633-636,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：2011年石家庄市科学技术研究及发展指导计划(No:11146403)

摘　　要：目的:研究Smac、XIAP、caspase-3在鼻腔鼻窦内翻性乳头状瘤(NIP)的发生、发展及癌变过程中的表达及意义。方法:选取正常鼻腔黏膜(NM)10例,NIP 45例。其中的NIP组根据不同的病理分级分为3组,即无不典型增生组(25例)、伴有不典型增生组(11例)、恶变组(9例),通过免疫组织化学SP法进行Smac、XIAP、caspase-3的检测。结果:Smac、Caspase-3在NIP组中的阳性表达强度弱于在NM组中的表达,在NIP不同病理分级中,阳性表达强度随病理分化程度的降低而降低,无不典型增生组及恶变组间的表达差异有统计学意义。XIAP在NM、NIP组中的阳性表达强度呈增强趋势,在NIP不同病理分级中,组织的分化程度越低,阳性表达强度越高,无不典型增生组及恶变组间的表达具有统计学意义。Smac与XIAP的表达为负相关(rs=-0.323,P<0.05),XIAP与caspase-3的表达负相关(rs=-0.408,P<0.01),Smac与caspase-3的表达为正相关(rs=0.424,P<0.01)。结论:Smac、XIAP、caspase-3与NIP的发病及恶变有关。Objective： To explore the expression and significance of second mitochondria derived activator of caspase（Smac） ,X-linked inhibitor of apoptosis protein（XIAP）and cysteine containing aspartate specific protease 3 （caspase-3） in the growth,development and carcinogenesis of the nonasal inverted papilloma（NIP）. Method： Immu- nohistochemical method was used to detect the expression of Smac,XIAP,caspase-3 in 10 cases of nasal cavity mu- cosae（NM）and 45 cases of NIP, the group of NIP including 25 cases of NIP without dysplasia, 11 cases of NIP with dysplasia, and 9 cases of NIP with malignant transformation to squamous cell carcinoma（SCC）. Result： The intensity of the positive expression of Smac,Caspase-3 in NIP were lower than NM, the intensity of the positive expression decreased with the decreasing degree of histological differentiation. There was a significant difference between NIP without dysplasia and SCC. It was presented with a progressive tendency for the expression of XIAP in the group of NM and NIP. The lower degree of histological differentiation, the higher intensity of the positive expression. The expression between NIP without dysplasia and SCC had a significant difference. Smac negatively correlated with XIAP （r2 = - 0. 323, P 〈 0.05 ）, XIAP negatively correlated with caspase-3 （r2 = - 0. 408, P 0.01）, Smac positively correlated with caspase 3 （ r2 = 0. 424, P〈 0.01）. Conclusion： Smac, XIAP, caspase 3 might be associated with the growth and carcinogenesis of NIP.

关 键 词：鼻腔鼻窦内翻性乳头状瘤 SMAC XIAP CASPASE-3 免疫组织化学 

分 类 号：R739.6[医药卫生—肿瘤]