MEGX试验对大鼠肝损伤时肝贮备功能的评估  

Evaluation of the liver reserve of the mice with experimental liver injury by MEGX test.

作　　者：钱国军[1] 陈汉[1] 姚晓平[1] 杨甲梅[1] 蒋平珍[2] 

机构地区：[1]第二军医大学东方肝胆外科医院 [2]第二军医大学附属长海医院临床药理研究室

出　　处：《华中医学杂志》2000年第1期21-22,F003,共3页Central China Medical Journal

摘　　要：目的　观察单乙基甘胺酰二甲苯胺 (MEGX)试验在大鼠肝损伤模型不同阶段的检测结果 ,以探讨 MEGX试验对肝功能评估的价值。方法　 30只健康 SD大鼠随机分成对照组和实验组 ,实验组以 6 0 %四氯化碳橄榄油皮下注射制作急性、慢性肝损伤模型。分别在 2周和 5周后行 MEGX试验、常规肝功能试验和组织学检查并对比。结果　正常组 MEGX试验数据 (x)为 193.40 ng/ ml,急性肝损伤组为 86 .92 ng/ m l,慢性肝损伤组为 135 .2 6 ng/ m l,与肝组织学变化较符合。而常规肝功能试验在急性、慢性肝损伤时均异常 ,但变化幅度与组织学变化不符合。结论　 MEGX试验与肝组织学变化更符合。Objective To study the outcome of MEGX test evaluating the liver reserve of the mice with liver injury in different phases.Methods 30 healthy SD mice were divided into experimental group and control group.The acute and chronic liver injury models were developed with CC14 oil liquid in the mice of the experimental group.MEGX test,common hepatic function test and histological examination were performed at 2nd week and 5th week respectively.Results MEGX test parameters in the control group,the acute liver injury group,the chronic liver injury group were 193.40 ng/ml, 86.92 ng/ml,135.26 ng/ml respectively,which were consistent with liver histological changes.However,the common liver function parameters were all abnormal in acute or chronic liver injury,which were not consistent with the liver histological changes.Conclusion MEGX test outcome was more agreement to liver histological changes than common liver function parameters.

关 键 词：MEGX试验 肝贮备功能 大鼠 肝损伤 

分 类 号：R363[医药卫生—病理学]