自噬与恶性肿瘤侵袭转移的相关性  

Autophagy and invasion and metastasis in malignant tumor

作　　者：翁军权[1] 侯劲松[1] 

机构地区：[1]中山大学附属口腔医院口腔颌面外科,广州510055

出　　处：《国际肿瘤学杂志》2012年第6期408-411,共4页Journal of International Oncology

基　　金：广东省自然科学基金资助项目（10151008901000025）;广东省科技计划项目（20098050700024、20098060700096）

摘　　要：在恶性肿瘤侵袭转移的复杂生物学过程中，肿瘤细胞必须适应不同的生存压力。自噬作为一种受诸多基因及其表达产物精细调控的细胞内生理反应，不仅可被激活以适应代谢应激和微环境变化，还可能与肿瘤细胞的上皮-间质转化（EMT）、肿瘤炎症、抵抗失巢凋亡、维持细胞休眠等侵袭转移机制密切相关。In the complex set of biological processes that a particular malignancy to metastasize, tumor cells must adapt to different survival pressures. As an important cell-physiologic response that under regulation of many genes and their expressions, autophagy not only can be strongly induced to adapt to metabolic stresses and microenvironmental changes, but also involved in the process of epithelial-mesenchymal transition （EMT） , restricting inflammation, resisting anoikis, maintaining dormancy in the metastatic process.

关 键 词：自噬 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]