经皮肝穿刺射频消融联合肝动脉化疗栓塞治疗原发性小肝细胞癌疗效分析  

Analysis of the therapeutic effect of percutaneous radiofrequency ablation combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma

作　　者：牟楠楠[1] 李响[2] 张乐[3] 

机构地区：[1]济南军区总医院超声诊断科,山东济南250031 [2]解放军第180医院普外科,福建泉州362000 [3]解放军第180医院胸外科,福建泉州362000

出　　处：《肝胆胰外科杂志》2012年第4期271-274,共4页Journal of Hepatopancreatobiliary Surgery

摘　　要：目的探讨经皮肝穿刺射频消融联合肝动脉化疗栓塞治疗原发性小肝细胞癌的疗效。方法回顾性分析2000年1月至2006年12月我院收治的162例原发性小肝细胞癌的临床资料,其中85例(第一组,共92个病灶)采用经皮肝穿刺射频消融联合肝动脉化疗栓塞治疗,77例(第二组,共85个病灶)采用单纯经皮肝穿刺射频消融治疗。结果第一组肿瘤完全坏死率为96%,1年、3年、5年的生存率及无瘤生存率分别为100%、85.2%、78.7%和87.5%、73.1%、65.7%;而第二组的肿瘤完全坏死率为92%,1年、3年、5年的生存率及无瘤生存率分别为100%、81.3%、72.3%和83.6%、68.7%、57.8%。两组间肿瘤完全坏死率,1年、3年、5年生存率及无瘤生存率的差异皆无统计学意义(P>0.05)。结论经皮肝穿刺射频消融联合肝动脉化疗栓塞治疗原发性小肝细胞癌的疗效与单纯采用经皮肝穿刺射频消融方法疗效相近,对于小肝细胞癌而言,单纯采用经皮肝穿刺射频消融方法是安全有效的。Objective To evaluate the therapeutic effect of percutaneous radiofrequency ablation （PRFA） combined with transcatheter arterial chemoembolization （TACE） for the small hepatocellular carcinoma. Methods From January 2001 to December 2005, 85 patients （group 1 with 92 lesions） with small hepatocellular carcinoma were treated with combined PRFA and TACE, while the other 77 cases （group 2 with 85 lesions） with small hepatocellular carcinoma were treated with PRFA alone, and their clinical data were collected and analyzed retrospectively. Results In group 1, the complete necrosis rate of lesions was 96%, the 1-, 3-, and 5-year overall survival rate after treatment were 100%, 85.2% and 78.7%, respectively. The 1-, 3-, and 5-year disease free survival rate were 87.5%, 73.1%, and 65.7%, respectively. In group 2, the complete necrosis rate of lesions was 92%. The 1-, 3-, and 5-year overall survival rate after treatment were 100%, 81.3% and 72.3%, respectively. The 1-, 3-, and 5-year disease free survival rate were 83.6%, 68.7%, and 57.8%, respectively. No significant difference was found between two groups concerning the complete necrotic rate of lesions, 1-, 3-, 5-year rate of overall survival and disease free survival. Conclusion Combined treatment of PRFA and TACE, and PRFA alone have equivalent effectiveness for the treatment of small hepatocellular carcinoma, so for the patients with small hepatocellular carcinoma, PRFA is a safe and effective treatment.

关 键 词：癌 肝细胞 经皮肝穿刺射频消融 肝动脉化疗栓塞 疗效 

分 类 号：R735.7[医药卫生—肿瘤]