牙周炎正畸牙周组织中胰岛素样生长因子-Ⅰ表达的实验研究  

Experimental study of insulin-like growth factor-Ⅰ expression in orthodontic tooth movement with periodontitis

作　　者：杨东红[1] 王石[2] 吴立鹏[1] 

机构地区：[1]黑龙江佳木斯大学口腔医学院,154002 [2]佳木斯大学附属第一医院

出　　处：《现代口腔医学杂志》2012年第4期262-265,共4页Journal of Modern Stomatology

基　　金：黑龙江省自然科学基金项目(D2007-87)

摘　　要：目的观察胰岛素样生长因子-I在牙周炎正畸牙移动过程中的表达,探讨其对炎性正畸牙周组织的影响。方法 36只wistar大鼠建立牙周炎动物模型,并随机平分为牙移动1天、3天、7天、14天、21天组及对照组,近中移动各实验组大鼠上颌第一磨牙,处死后制取牙周组织标本,行HE染色和免疫组化分析。结果在既定时间内,IGF-Ⅰ在压力侧和张力侧均有阳性表达,在加力第3天两侧表达均达到峰值,但强度较弱。结论 IGF-Ⅰ在正畸牙周组织改建中,参与了炎症正畸牙周组织改建过程,影响张力侧的成骨活动和压力侧的破骨活动。Objective To observe effection of insulin-like growth factor-I during orthodontic tooth movement in periodontal tissue, and to explore the effeetion of IGF-I on inflammatory orthodontics. Methods Thirty-six Wistar rats after establishment animal model of periodontitis, were randomly divided into periodontitis tooth movement 1 day, 3 days, 7 days, 14 days, 21 days and compared group. Moved mesially the maxillary first molar, and made periodontal tissue for HE staining and immunohistoehemical analysis. Results In a given period of time, IGF- I in the pressure and tension sides were positive, the third day the immunohistochemical of IGF- I were reached the maximum,but the intensity was weak. Conclusion IGF- I acted in tissue remodeling during orthodontic tooth movement, not only affected the tension side of bone formation activity, but also affected the pressure side of osteoclast activity.

关 键 词：牙周炎 牙周组织改建 胰岛素样生长因子-Ⅰ 

分 类 号：R783.5[医药卫生—口腔医学]