短暂性脑缺血发作患者血清超敏C反应蛋白、尿酸水平的变化及其临床意义  

Clinical Significance of High Sensitivity C - reactive Protein and Serum Uric Acid in Patients with Transient Ischemic Attack

作　　者：马磊[1,2] 于园园[2] 范学文[3] 

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院急诊科,银川750004 [3]宁夏医科大学总医院心脑血管病医院神经内科,银川750004

出　　处：《宁夏医科大学学报》2012年第7期692-694,698,共4页Journal of Ningxia Medical University

摘　　要：目的探讨不同病程的短暂性脑缺血发作(TIA)患者血清超敏C反应蛋白(hs-CRP)、血清尿酸水平的差异。方法 84例临床诊断TIA首次发作患者按病程分为A、B、C三组,即TIA持续60 min内缓解为A组,TIA超过60 min并反复发作,但无持久的神经功能缺损症状,影像学检查证实无脑梗死发生者为B组,C组为TIA起病后发展为脑梗死,在48～72 h经头颅CT或MRI证实有脑梗死发生。所有患者入院后检测血清hs-CRP及血清尿酸含量,28例健康体检者作为对照组,分析TIA的危险因素,并进行hs-CRP与尿酸水平的相关性研究。结果①四组研究对象hs-CRP和血尿酸水平差异均具有统计学意义,经多重比较C组hs-CRP和血尿酸水平均高于A组和B组(P<0.01),B组高于A组和对照组、A组较对照组高。②Logistic回归分析显示高尿酸血症、高hs-CRP、血脂异常、高血压、糖尿病为TIA的危险因素。③血清hs-CRP和血清尿酸水平呈正相关(r=0.71,P<0.01)。结论血清hs-CRP和尿酸水平升高可能是TIA的危险因素,临床检测血清hs-CRP和尿酸水平,可为TIA患者的病情评估提供可靠信息。Objective To explore the clinical significance of high sensitivity c-reactive Protein and serum uric acid in patients with transient ischemic attack.Methods 84 TIA patients were divided into three groups of A,B,C.Group A： TIA could be relieved in 60 minutes.Group B： TIA lasted for more than 60 minutes,but there were no neurological deficit and cerebral infarction,TIA.Group C.TIA deteriorated into cerebral infarction by CT or MRI within 48-72 hours.The high sensitivity c-reactive protein and serum uric acid level was determined in all patients within 24 hours separately.28 healthy subjects were used as control group.Results ①The high sensitivity c-reactive protein and serum uric acid levels of four groups were significantly different,.The above incices in group C were higher than those of group A and B（P 〈 0.01）.②It showed that high levels of c-reactive protein and serum uric acid,hypertension,diabetes and dyslipidemia were the risk factors in patients with TIA with Logistic regression analysis.③ The correlative analysis of all groups demonstrated that high sensitivity c-reactive protein and serum uric acid had significantly positive correlation（r =0.71,P 〈0.01）.Conclusion The increase of the level of high sensitivity c-reactive protein and serum uric acid are the probable risk factors of TIA.It can also provide useful information for patients with TIA by determining the level of high sensitivity c-reactive protein and serum uric acid.

关 键 词：短暂性脑缺血发作 超敏C反应蛋白 血尿酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]