δ-氨基酮戊酸光动力学疗法治疗皮肤癌前病变和皮肤原位癌的疗效评价  

δ-Aminolaevulinic acid-photodynamic therapy in the treatment of precancerous changes and carcinoma of the skin

作　　者：杜鹏[1] 曹萍[1] 张桂琼[1] 金梅[1] 

机构地区：[1]云南省第一人民医院皮肤性病科,云南昆明650031

出　　处：《中国现代医生》2012年第20期152-154,共3页China Modern Doctor

摘　　要：目的探讨δ-氨基酮戊酸光动力疗法（ALA—PDT）治疗皮肤癌前病变和皮肤原位癌的疗效。方法局部ALA—PDT治疗32例基底细胞癌、9例Bowen病、8例日光性角化病和2例女性外阴白斑患者。结果经3-6次治疗，除BCC完全缓解率为93．75％外，其余患者的皮损均可达完全缓解，完全缓解率为100％；经过3～11个月随访，除3例BCC及1例Bowen病患者外，其余患者均未见复发，其复发率分别为9．4％和11％。结论ALA—PDT是一种疗效好、无明显痛苦、无瘢痕形成、复发率低、美容效果好的治疗皮肤癌前病变和皮肤原位癌的新疗法；特别适合于头面部及外生殖器部位的多发性、较大面积皮损。Objective To investigate the effects of δ-aminolaevulinic acid-photodynamic therapy（ALA-PDT） on precancerous changes and carcinoma of the skin. Methods Thirty-two patients with BCC,9 patients with Bowen＇s disease, 8 patients with ac-tinic keratosis and 2 patients with leukoplakia were treated by ALA-PDT. Results The clearance was achieved in 30 patients with BCC,9 patients with Bowen＇s disease,2 patients with leukoplakia and 8 patients with actinic keratosis by topical ALA-PDT were completed remission.The recurrence rates were 9.4% and 11% for three cases BCC and one Bowen＇s disease,respectively. Conclusion Topical ALA-PDT is a simple,effective and new treatment with lower recurrent rates,no scar formation and excellent cosmetic results for precancerous changes and carcinoma in situ of the skin,especially for the large and multifocal lesions located on the face and external genitalia.

关 键 词：氨基酮戊酸 光动力学疗法 基底细胞癌 BOWEN病 

分 类 号：R739.5[医药卫生—肿瘤]