卵圆孔未闭与中青年缺血性脑卒中的关系  

Analysis of the occurrence of patent foramen ovale in young patient with ischemic stroke

作　　者：郭鸿昌[1] 高敬[1] 王彩荣[1] 张科峰[1] 高承梅[1] 李晓辉[1] 徐东[1] 

机构地区：[1]首都医科大学宣武医院心脏中心,北京100053

出　　处：《北京医学》2012年第7期549-551,共3页Beijing Medical Journal

摘　　要：目的探讨中青年缺血性脑卒中患者卵圆孔未闭(patent foramen ovale,PFO)的发生情况以及危险因素。方法选择中青年缺血性脑卒中患者127例,分为PFO组77例和无PFO组50例。经食管超声心动图及右心声学造影检查,观察PFO的发生情况及缺损大小。结果 PFO组的年龄(34±12)岁低于无PFO组(40±10)岁,差异有统计学意义(P=0.002)。PFO组合并缺血性脑卒中的危险因素(高血压、糖尿病、吸烟史、高脂血症、高同型半胱氨酸血症)比例明显低于无PFO组,差异有统计学意义(P<0.05)。PFO组经颅多普勒超声和颈动脉超声检查脑血管未见明显病变的病例比例低于无PFO组,差异有统计学意义(P<0.05)。结论 PFO可能是中青年缺血性脑卒中发病的重要原因。Objective To investigate the occurrence of patent foramen ovale （PFO） in young patients with ischemic stroke. Methods A total of 127 young patients with ischemic stroke were admitted to the inpatient department of XuanWu Hospital, Capital Medical University from July 2008 to July 2010. They were divided into a PFO group （n =77） and a non-PFO group （n=50） by transesophageal echocardiography（TEE）. Results Patients in the PFO group were younger than those in the non-PFO group （34 ±12 vs. 40 ±10）, the difference was statistically significant （P 〈 0.05）. PFO group had lessstroke related risk factors than those of the non-PFO group in the, such as hypertension, diabetes mellitus, smoking history of smoking, hypercholesterolemia and Hyperhomocysteinemia. The difference was statistically significant （P 〈 0.05）. The PFO group had less negative pathological changes by TCD and carotid ultrasound than those of the non-PFO group in. Conclusion PFO may be a key factor for ischemic stroke in young patients.

关 键 词：脑卒中 卵圆孔未闭 房间隔膨胀瘤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]