肠道病毒71型基因工程疫苗研究进展  

Development of genetically engineered enterovirus 71 vaccine

作　　者：李玫颖[1,2] 姚昕[1] 梁争论[1] 

机构地区：[1]中国食品药品检定研究院,北京100050 [2]沈阳药科大学生命科学与生物制药学院,辽宁沈阳110016

出　　处：《中国病毒病杂志》2012年第4期315-319,共5页Chinese Journal of Viral Diseases

基　　金：国家科技支撑计划(2008BAI69B01);国家"十一五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2009ZX10004-804)

摘　　要：近年来,手足口病（hand foot and mouth disease,HFMD）在我国呈持续流行态势,其中肠道病毒71型（enterovirus71,EV71）感染易导致严重和死亡病例,造成巨大的社会负担,HFMD已成为政府和社会高度关注的公共卫生问题。Enterovirus 71（EV71） epidemics occur frequently in China's Mainland during recent years.EV71 infections are usually self limiting,characterized as hand,foot,and mouth disease（HFMD）,herpangina or aseptic meningitis;but severe neurological complications such as encephalitis and poliomyelitis-like paralysis with high mortality were also reported,constituting an important issue in public health.Vaccination is a very effective approach to control the infection and circulation of the disease.Among different types of EV71 vaccines which include inactivated whole virus,live-attenuated virus,recombinant viral protein,virus-like particle（VLP） and DNA vaccines.This review focuses on the development of genetically engineered non-infectious vaccines.

关 键 词：肠道病毒71型 手足口病 基因工程疫苗 

分 类 号：R392.1[医药卫生—免疫学]