CCI模型大鼠疼痛行为学观察  

The Pain Behavior of Rat After Chronic Constriction Injury of the Sciatic Nerve

作　　者：冯昌盛[1] 余庆波[1] 杨丹[1] 涂发平[1] 

机构地区：[1]川北医学院附属医院,四川南充637000

出　　处：《中国医学创新》2012年第20期12-14,共3页Medical Innovation of China

摘　　要：目的:探讨CCI(Chronic constrictive injury)模型大鼠一般行为学及痛阈变化。方法:SD(Sprague-Dawley)大鼠48只,6～8周龄,雄性,体重180～200g。随机分为三组,即正常对照组(Nave组:n=16,分7、14d亚组,每亚组8只)、假手术组(Sham组,n=16,分7、14d亚组,每亚组8只)以及CCI组(n=16,分7、14d亚组,每亚组8只)。按Bennet和Xie方法制作CCI模型,通过von Frey测定大鼠神经结扎侧(左侧)及对侧(右侧)后足缩足反射阈值(Mechanical withdrawal threshold,MWT)。结果:与假手术组和正常对照组比较,CCI组大鼠术侧痛阈在术后第3、6、8、10、13天明显降低,且低于术前基础值。结论:CCI大鼠行为学的改变与痛阈的变化有一定联系。Objective：The pain behavior and mechanical withdrawal threshold of rat after chronic constriction injury of the sciatic nerve were discussed.Method：Sprague-Dawley rats were divided into three groups：naive group（this group is divided into two subgroups：sham 7 d,14 d,n=8 in each subgroup）,sham group（this group is divided into two subgroups：sham 7 d,14 d,n=8 in each subgroup）,CCI group（this group is divided into two subgroups：sham 7 d,14 d,n=8 in each subgroup）.Meanwhile,mechanical allodynia was tested by a series of von Frey device at special time point after surgery,respectively.Result：The mechanical withdrawal threshold.was dramatically decreased at 3 d,6 d,8 d,10 d or 13 d after the CCI surgery comparison with sham operation.Conclusion：It is a close relationship between the pain behavior and mechanical withdrawal threshold of rat after chronic constriction injury of the sciatic nerve.

关 键 词：CCI模型 大鼠 疼痛行为学 痛阈 

分 类 号：R-332[医药卫生]