脑动静脉间脉搏波传导时间对腔隙性脑梗死的初步评价  

A preliminary study on the relationship between lacunar infarction and cerebral arerio-venous pulse wave time

作　　者：周艳霞[1,2,3] 高庆春[1] 杨容坤[1] 黄楚明[1] 陈秀梅[1] 

机构地区：[1]广州医学院第二附属医院神经内科,广州510260 [2]广州医学院 [3]深圳市第二人民医院神经内科

出　　处：《中国神经精神疾病杂志》2012年第7期393-396,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省卫生厅缺血性卒中患者脑血管储备功能和介入治疗作用的观察(编号:A2008273)

摘　　要：目的探讨脑动静脉间脉搏波传导时间(cerebral arerio-venous pulse wave time,CAV-PWT)与腔隙性脑梗死(lacunar infarction,LI)的相关性。方法按照病例对照研究方法,采集40例LI患者和20例对照组人口学资料和相关危险因素。采用经颅多普勒(transcranial dopple ultransonograp,TCD)仪同步监测颈内动脉终末段(terminal internal carotid artery,TICA)与基底静脉(Rosenthal’s veins;venae basalis,BVR)的脉搏波,计算CAV-PWT,比较2组间CAV-PWT的差异,以及分析CAV-PWT与人口学资料和危险因素间的关系。结果病例组患者的CAV-PWT(73.53±15.81 ms)与对照组(106.02±28.06 ms)比较明显缩短(P<0.05)。多元回归分析显示:CAV-PWT与体重指数X1和年龄X3负相关(rs=-0.697与-0.3258,P<0.05),与头围、性别、血糖、血脂和血压无明显相关性。回归方程Y=210.168-4.661X1-0.459X3。Logistic回归分析显示:年龄X3、PWTX4和高血压X9是LI的危险因素(P<0.05),其回归方程logit P=-8.034-2.178X1+5.066X3+3.775X4+4.865X9(掊2=20.181,P<0.01)。结论LI患者CAV-PWT明显缩短,可能与脑小动脉硬化有关。Objective To investigate the relationship between cerebral arerio-venous pulse wave time （CAV-PWT） and lacunar infarction. Methods Forty patients with lacunar infarction and 20 sex-and-age-matched control subjects were studied. The pulse wave of terminal intemal carotid artery and basal vein were simultaneously monitored by TCD and the CAV-PWTs were then calculated. The difference in CAV-PWT between patients and controls and the relationships of CAV-PWT with demographic data and risk factors were analyzed. Results The CAV-PWT was signif- icantly shorten in patient group than in control group （73.53 ± 15.81 ms vs 106.02 ±8.06 ms） （P 〈 0.05）. Multi- ple linear regression revealed that CAV-PWTs were negatively correlated with body mass index and age （ra=-0.697 and -0.3258, P 〈 0.05）, but not with head circumference, gender, blood sugar, blood fat or blood pressure. The regression equation was： Y = 208.928-4.661X1-0.459X3 （F = 22.358, P 〈 0.001） Logistic regression analysis showed that age, PWT and high blood pressure were risk factors for lacunar infarction（P 〈 0.05）. The regression equation was logit P =-8.034 ＋ 5.066X3 ＋ 3.775X4 ＋ 4.865X9（X^2 = 20.181, P 〈 0.01）. Conclusions The CAV-PWT is significantly shorten in lacunar infarction, which may be associated with cerebral arteriolosclerosis.

关 键 词：腔隙性脑梗死 脉搏波传导时间 经颅多普勒 小动脉硬化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]