精神分裂症与NOS1多态性的关联研究  

Association study of NOS1 gene polymorphisms and schizophrenia

作　　者：王佳[1] 马小红[1,2] 向波[1] 吴俊瑶[1] 王英成[1] 邓伟[2] 李名立[2] 王强[2] 何宗岭[2] 李涛[1,2] 

机构地区：[1]四川大学生物治疗国家重点实验室精神医学研究室,成都610041 [2]华西医院心理卫生中心

出　　处：《中华医学遗传学杂志》2012年第4期459-463,共5页Chinese Journal of Medical Genetics

摘　　要：目的探讨一氧化氮合酶1（nitric oxide synthase 1，NOSl）基因多态性与精神分裂症易感性的相关性。方法选取NOSl区域的28个标签单核苷酸多态性（single nucleotide polymorphisms，SNPs）位点，应用IlluminaGoldenGate定制芯片对382例汉族精神分裂症患者和448名正常人的DNA进行分型，并分析其与精神分裂症的相关性。结果单位点分析提示SNP位点rsl520811与精神分裂症存在关联，但是经过Bonferroni多重校正后差异无统计学意义（P〉0．05）。单体型分析未发现单体型与精神分裂症的相关性。结论未证实NOS1为精神分裂症的易感基因。Objective To assess the polymorphisms and schizophrenia. Methods association between nitric oxide synthase 1 （NOS1）gene Twenty eight tag single nucleotide polymorphisms （SNPs） of NOS1 in 382 schizophrenic patients and 448 healthy individuals sampled from Chinese Han population were analyzed by a Illumina GoldenGate Genotyping Assay. Results One SNP （rs1520811） was found to be associated with schizophrenia, which however becomes negative after Bonferroni correction （P^0.05）. Further analysis has failed to identify any association between particular haplotypes and the disease. Conclusion Our results did not support a significant association between NOS1 gene polymorphisms and schizophrenia.

关 键 词：精神分裂症 一氧化氮合酶1基因 单核苷酸多态性 关联分析 

分 类 号：R749.3[医药卫生—神经病学与精神病学]