细胞周期调节蛋白在复发鼻咽癌中的表达及意义  

Expression and clinical significance of cell cycle regulators in relapsing nasopharyngeal carcinoma

作　　者：蒋昌斌[1] 易炜[1] 何芬[1] 秦海燕[1] 李蓉[1] 孙建聪[1] 万明辉[1] 

机构地区：[1]广州医学院第一附属医院放疗科,广东广州510230

出　　处：《热带医学杂志》2012年第7期807-809,F0004,共4页Journal of Tropical Medicine

基　　金：广州市医学科学技术研究基金(2009-YB-152)

摘　　要：目的通过对68例鼻咽癌复发患者癌组织中细胞周期调节蛋白水平的检测,进行鼻咽癌复发的趋势预测和探讨可能的机制。方法采取免疫组织化学法对所有研究对象的组织标本进行p53、MDM2、p21WAF1、p21ras、VEGF的检测。结果 68例患者平均复发间期为(31.65±24.52)月。未发现不同分期的复发间期差异有统计学意义(P=0.361)。单因素分析发现高表达的MDM2水平会缩短复发间期(P=0.016)。多因素分析显示年龄(≥50岁)、高表达MDM2和低表达或阴性p21WAF1是复发间期的影响因素。结论年龄较大、高表达MDM2、低表达或阴性p21WAF1的鼻咽癌患者易较早出现复发。Objective To investigate the expression and clinical significance of cycle dependent kinase in nasopharyngeal carcinoma （NPC）. Methods The expression of p53,MDM2,p21WAn,p21^ras,VEGF protein in 68 specimens of nasopharyngeal carcinoma was examined by immunohistochemistry. Results The average relapse-interval of the 68 patients was （31.65± 24.52） months. No significant difference of relapse-interval in clinical stage was found （P=0.361）. Univariate analysis suggested that the patients with high-expression of MDM2 protein had a shorter relapse-interval than the control group （P=0.016）. Multivariate analysis indicated that age, MDM2 or p21war＇ were the independent relapse predictors. Conclusion Old age, the high-expression of MDM2 and the low or negative-expression of p21wsn might further accelerate the process of relapse.

关 键 词：鼻咽肿瘤 P53 MDM2 P21 VEGF 

分 类 号：R739.63[医药卫生—肿瘤]