结直肠癌合并肠梗阻的临床病理学研究  

Study on clinical pathological correlative factors of obstruction in patients with colorectal carcinoma

作　　者：许慕明[1] 庄业忠[1] 王伟峰[1] 林佳锐[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院外科,广东汕头515031

出　　处：《热带医学杂志》2012年第7期840-842,共3页Journal of Tropical Medicine

基　　金：汕头市重点科技项目(汕府科[2011]46号)

摘　　要：目的探讨结直肠癌合并肠梗阻的相关影响因素。方法收集466例结直肠癌患者的临床病理资料,分析肠梗阻与患者临床病理因素的关系。结果全组病例肠梗阻发生率为8.2%(38/466)。单因素分析显示,肠梗阻与性别、肿瘤大小、大体类型、淋巴结转移、远处转移、TNM分期、术前血清癌胚抗原水平以及手术方式相关;Logistic回归分析显示,影响肠梗阻发生的因素为大体类型、年龄、TNM分期和肿瘤大小;其危险程度大小为大体类型>年龄>TNM分期>肿瘤大小。结论结直肠癌合并肠梗阻的特征是好发于中老年人,病程晚,生物行为恶及根治率低。Objective To reveal the clinical pathological correlative factors of obstruction in patients with colorectal carcinoma. Methods The clinicopathological data of 466 patients who underwent radical or palliative surgery of colorectal carcinoma during Nov 2008 to Nov 2011 in our department were collected. And then the relationships between obstruction and the patients＇ other clinicopathological factors were statistically analyzed. Results The rate of obstruction in all patients was 8.2% （38/466）. After x22 tested, it showed that obstruction was correlated with gender, tumor size, massive type of tumor, regional lymph node metastasis, distant metastasis, TNM stage, preoperative serum CEA level and surgical modality. Logistic regression analysis indicated obstruction was correlated with massive type of tumor, age, TNM stage and tumor size. The most hazardous factor that impacted on obstruction was massive type of tumor, followed by age, TNM stage and tumor size. Conclusion The features of colorectal carcinoma complicated with obstruction were ： occurring more frequently in the middle- aged and the elderly than in the young, late course of disease, bad biological behavior and low radical resection rate.

关 键 词：结直肠癌 肠梗阻 相关因素 

分 类 号：R735.35[医药卫生—肿瘤]