胃泌素释放肽前体作为小细胞肺癌标记物的临床意义探讨  

Clinical significance of serum progastrin-releasing peptide(Pro-GRP) detection in small cell lung cancer

作　　者：秦家濂 吴金燕[2] 

机构地区：[1]深圳市宝安区人民医院检验科,广东深圳518100 [2]广东医学院检验学院,广东东莞523808

出　　处：《热带医学杂志》2012年第7期861-863,共3页Journal of Tropical Medicine

摘　　要：目的探讨胃泌素释放肽前体(Pro-GRP)作为小细胞肺癌(SCLC)新标记物的临床意义,并与神经元特异性烯醇酶(NSE)进行比较。方法用雅培化学发光分析仪I2000(美国产)测试血清中Pro-GRP水平,比较86例SCLC初治患者血清中Pro-GRP与NSE水平,分析Pro-GRP诊断SCLC的灵敏度、特异度。分析化疗前后患者血清NSE和Pro-GRP水平与生存率的关系及相关性,采用ROC曲线确定阈值,比较诊断准确性。结果血清Pro-GRP诊断SCLC的敏感性和特异性分别为88.37%和93.82%。化疗后,Pro-GRP和NSE水平均下降。在复发/进展的患者中,Pro-GRP的阳性率显著高于NSE(P<0.05)。Pro-GRP和NSE在SCLC诊断中的分布有明显的相关性(r=0.256,P<0.01)。结论 Pro-GRP是较NSE更为特异、敏感的SCLC肿瘤标志物,还可以反映疗效,监测复发。Objective To study the clinical significance of serum pro-gastrin-releasing peptide （Pro-GRP） detection in small cell lung cancer, and compare with neuron-specific enolase （NSE） detection. Methods The serum levels of ProGRP and NSE of 86 patients with SCLC were compared, and analyze for their diagnostic sensitivity and specificity, and their correlation with survivorship before and after the chemotherapy. The receiver operating characteristic （ROC） curve was used to set the cutoff value and evaluate the diagnostic accuracy. Results The diagnostic sensitivity and specificity of Pro-GRP in SCLC were 88.37% and 93.82%, respectively. The concentration of Pro-GRP and NSE decreased after chemotherapy.In patients with relapsed or progressed SCLC, the positive rate of Pro-GRP was significantly higher than that of NSE. Pro-GRP and NSE have apparent correlation with the diagnosis of cell lung cancer（r=0.256, P〈0.01）. Conclusion Pro-GRP is a more specific and sensitive marker than NSE for the diagnosis of SCLC, which could also reflect the therapeutic effect and monitor relapse .

关 键 词：小细胞肺癌 胃泌素释放肽前体 神经元特异性烯醇 

分 类 号：R734.2[医药卫生—肿瘤]