SOX2在胃癌组织中的表达与临床意义  

Expression of SOX2 in gastric carcinoma tissues and its clinicopathologic significance

作　　者：陈淑贞[1,2] 许玲[2] 刘凤军[3] 宋燕燕[2] 薛凤华[1,2] 张建平[1,2] 

机构地区：[1]山东大学齐鲁医院病理科,山东济南250012 [2]山东大学医学院,山东济南250012 [3]山东大学齐鲁医院普外科,山东济南250012

出　　处：《中国现代普通外科进展》2012年第7期537-540,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨SOX2在胃癌组织中的表达情况及与临床病理特征的关系。方法:应用组织芯片技术及免疫组织化学PV-9000通用二步法检测130例胃癌组织及20例正常胃黏膜中SOX2的表达情况。结果:SOX2在胃癌组织中的阳性表达率(67.7%)低于较正常胃黏膜阳性率(90.0%,P<0.05)。SOX2的表达与患者的年龄、性别无关,与肿瘤的组织学类型、分化程度、浸润深度、淋巴结转移及TNM分期相关,差异均有统计学意义(P<0.05)。结论:SOX2与胃癌的发生、浸润和转移过程有密切关系,可为胃癌早期诊断、治疗、预后判断提供依据。Objective：To investigate the expression of SOX2 in gastric carcinoma and analyze its relationship with clinicopathologic characteristics.Methods：Tissue microarray and immunohistochemical methods were performed to detect the expression of SOX2 in 130 cases of gastric carcinoma and 20 cases normal gastric mucosa.Results：The positive expression rate of SOX2 in gastric carcinoma（67.7%） was obviously down regulated than in normal gastric mucosa（90.0%）.The expression of SOX2 was not related to the age and sex of the patients,but significantly associated with histological type,differentiation,depth of invasion,lymph node metastasis and TNM stage of the tumor.The statistical significance in the each group was assessed by P〈0.05.Conclusion：The results suggest the expression of SOX2 is closely related to the genesis,invasion and metastasis of gastric carcinoma,and may provide a potential role for prognosis.

关 键 词：胃肿瘤 SOX2 基因表达 病理学 临床 

分 类 号：R735.2[医药卫生—肿瘤]