手术导航系统辅助下放射粒子植入治疗眶尖周、颅底肿瘤的探索  

The use of surgical navigation system in brachytherapy of tumors in orbital apex and skull base

作　　者：任仪鹏[1] 步荣发[1] 张蕾[1] 黄雪蕾[1] 

机构地区：[1]解放军总医院口腔颌面外科,北京100853

出　　处：《中国口腔颌面外科杂志》2012年第4期338-341,共4页China Journal of Oral and Maxillofacial Surgery

摘　　要：目的:将手术导航系统与放射性粒子内照射治疗相结合,探索更高精度植入125I放射粒子的方法,从而更加安全有效地控制已累及颅底及眶尖周的口腔颌面部恶性肿瘤。方法:肿瘤侵及颅底、眶尖周的腺样囊性癌患者11例,术前进行MRI扫描。术中运用BrainLAB手术导航系统定位并引导手术进行。结果:术中避免了颅脑及眶内组织损伤。完成了放射粒子组织内均匀分布,定位准确,无一例出现颅脑损伤及视力影响,治疗有效率(response rate,RR)达100%,疗效确切。结论:手术导航系统辅助下进行颅底眶尖周放射粒子植入是精确、安全的,有条件的情况下可考虑采用。PURPOSE：The aim of this study was to find a more precise and safe way to implant radioactive particles into the cranial base and orbital regions using the operation navigation system.METHODS：Eleven patients with invasive adenoid cystic carcinoma of the cranial base and orbital apex and a history of multiple surgeries were selected.A preoperative magnetic resonance scan was performed and the German BrainLAB surgical navigation system was used to aid the surgery.RESULTS：No intracranial injury or visual impairment occurred,and the response rate was 100%.CONCLUSION：This study indicates that the implantation of radioactive particles using the operation navigation system was an effective and safe method for treating tumors in the skull base and orbital apex,and should be considered for clinical use.

关 键 词：放射粒子 MRI 导航 颅底肿瘤 

分 类 号：R473.73[医药卫生—护理学]