普萘洛尔治疗婴幼儿血管瘤的作用机制研究进展  

The mechanisms of propranolol treatment for infantile hemangiomas and advances in research

作　　者：张凌[1] 麦华明[1] 郑家伟[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面外科,上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2012年第4期342-346,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(81070846)~~

摘　　要：血管瘤是婴幼儿最常见的良性肿瘤,在1岁以下婴儿中的发病率约为10%,其中约60%发生于头颈部。少数重症或多发性血管瘤可继发严重并发症,影响外形、功能甚至危及生命,必须早期进行干预。研究发现,普萘洛尔治疗婴幼儿血管瘤具有良好效果,但其具体作用机制尚不清楚。本文对普萘洛尔治疗血管瘤的作用机制及研究进展做一综述。[Summary] Hemangioma is the most common benign tumor in infancy,with a high incidence rate of 10% under one year of age,of which about 60% happen in the head and neck.The tumors can cause functional and/or esthetic problems and even become life threatening in some children if left untreated,therefore,early diagnosis and intervention are necessary in most patients.Propranolol was found accidently effective for infantile hemangiomas,but its mechanism remains unclear.In this paper,we reviewed the mechanism of action of propranolol in infantile hemangioma treatment and recent advances both in clinical and basic researches.

关 键 词：普萘洛尔 婴幼儿血管瘤 作用机制 

分 类 号：R739.5[医药卫生—肿瘤]