microRNA在乳腺癌诊断及预后判断中的作用  

Contribution of microRNAs in diagnosis and prognosis of breast cancer

作　　者：曹志刚[1] 邵志敏[1] 

机构地区：[1]复旦大学附属肿瘤医院乳腺外科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国癌症杂志》2012年第7期542-546,共5页China Oncology

摘　　要：乳腺癌是全球女性患病率最高的恶性肿瘤,严重危害广大女性的健康。微小RNA(microRNA,miRNA)是一类小的内源性非编码RNA,通过与mRNA 3’端非翻译区部分互补配对,在翻译后水平调节靶基因的表达。miRNA在乳腺的发育过程中发挥多种作用,其表达异常可能导致乳腺癌的发生。乳腺癌中miRNA的异常表达,以及miRNA在血清中的稳定存在,使miRNA有望成为新的生物标志物用于乳腺癌的诊断及预后判断。Breast cancer is the most common malignancy affecting women worldwide, microRNAs （miRNAs）, a class of short endogenous non-coding RNA, act as post-transcriptional regulators for target gene expression by binding to partially complementary 3＇untranslated regions of target mRNA. miRNAs have multiple functions in breast development, and abnormal expression of miRNAs could lead to breast tumorigenesis. The different expression profiles of miRNAs in breast cancer, and the stability of miRNAs in serum, all together make them as new potentially clinical biomarkers for diagnosis and prognosis of breast cancer. This review focused on the function of miRNAs in the diagnosis, prognosis of breast cancer.

关 键 词：乳腺癌 MICRORNA 诊断 预后 

分 类 号：R737.9[医药卫生—肿瘤]