依托泊苷脂质微球注射液对人肺癌H460细胞裸鼠移植瘤的生长抑制作用  

The effect of etoposide liposome on the mouse with lung cancer H460

作　　者：武珊珊[1] 郑辉[2] 

机构地区：[1]北京军区总医院胸外科,北京100700 [2]中国疾病预防控制中心辐射防护与核安全医学所,北京100088

出　　处：《现代肿瘤医学》2012年第8期1554-1557,共4页Journal of Modern Oncology

摘　　要：目的:观察依托泊苷脂质微球注射液抑制肺癌H460细胞裸鼠移植瘤生长的作用。方法:采用人肺癌H460瘤株种植于裸鼠皮下,形成移植瘤模型,用依托泊苷脂质微球注射液静脉注射,对抑制荷瘤动物肿瘤生长作用进行观察。结果:依托泊苷脂质微球注射液具有明显的抑制荷瘤动物肿瘤生长作用;依托泊苷脂质微球注射液抑瘤生长作用与依托泊苷注射液比较无明显差异。对血液WBC和脏器损伤轻于依托泊苷注射液。结论:依托泊苷脂质微球注射液治疗肺癌具有安全、有效,不良反应低,耐受性好的特点。Objective：To observe the effects of restraint cancer growup in mouse carry lung cancer H460 cell strain by etoposide liposome. Methods： Lung cancer H460 cell strain was transferred into mouse to induce the ani- mal model and observe the effects of restraint cancer growup in mouse with lung cancer H460 by etoposide liposome. Rusults： The etoposide liposome had the effects of restraint lung cancer H460 cell strain growing up. The etoposide liposome had same antitumor activity compared, with the etoposide, and had lower toxicity for blood WBC and tissues than etoposide. Conclusion： Etoposide liposome for lung cancer is effective and less toxicity.

关 键 词：依托泊苷脂质微球注射液 肺癌H460瘤株 抑瘤生长 

分 类 号：R73-361[医药卫生—肿瘤] R734.2[医药卫生—临床医学]