术前CEA和CA15-3对乳腺癌的临床应用价值  

Clinical value of preoperative CEA and CA15-3 in breast cancer

作　　者：陈彼得[1] 吴三纲[2] 何振宇[3] 林勤[2] 管迅行[3] 

机构地区：[1]厦门大学附属第一医院核医学科,福建厦门361003 [2]厦门大学附属第一医院放疗科,福建厦门361003 [3]中山大学肿瘤防治中心放疗科,广东广州510060

出　　处：《现代肿瘤医学》2012年第8期1610-1613,共4页Journal of Modern Oncology

基　　金：广东省科技计划社会发展项目(编号:2008B060600019)

摘　　要：目的:探讨术前CEA和CA15-3对乳腺癌早期诊断的价值及其与临床病理因素的相关性。方法:回顾性分析2000年-2005年1028例乳腺癌患者的CEA、CA15-3水平以及与临床病理因素的关系。结果:CEA、CA15-3联合检测、CA15-3及CEA单独检测对乳腺癌的早期诊断敏感性均低,分别为20.9%、15.3%、9.5%;CA15-3和CEA联合检测在肝、骨和肺转移的阳性率则分别为86.7%、90.9%、45.5%(P=0.030),CA15-3、CEA单独检测对转移病灶的敏感性无差异(P均>0.05)。CEA、CA15-3单独检测及CEA、CA15-3联合检测的阳性率与乳腺癌的临床分期、T分期、N分期呈正相关性,(P均<0.001)。CEA单独检测的阳性率与年龄>45岁、绝经后、ER阴性、PR阴性、Her2阳性有显著相关性(P均<0.05);除CEA、CA15-3联合检测的阳性率与Her2阳性呈正相关,联合检测及CA15-3单独检测与其他因素无相关性。结论:术前CEA和CA15-3对乳腺癌的早期诊断缺乏敏感性,但可作为预测预后的重要指标。Objective：To investigate the value of preoperative carbohydrate carcinoembryonic antigen （CEA） and antigen 15 - 3 （ CA 15 - 3 ） in the early diagnosis of breast cancer and the association between tumor markers and clinicopathological parameters. Methods： We retrospectively studied CEA, CA15 = 3 and clinical pathological factors of 1028 breast cancer patients diagnosed between 2000 and 2005. Results： Increased CEA and CA 15 -3 concentra- tions were found in 9.5% and 15.3% of the patients, respectively, and 1 or both tumor markers were only increased in 20.9%. Tumor marker measurements can contribute usefully to early detection the site of distant metastatic dis- ease, 1 or both tumor markers concentrations were increased in liver, bone and lung distant metastatic disease with 86.7% ,90.9% ,45.5% （P =0.030） ,respectively. The sensitivity of CEA and CA 15 -3 concentrations of detection of metastatic site was no significant different （ all P 〉 0.05 ）. Increased lerll in each tumor marker correlated with clinical stage, larger tumor sizes and nodal involvement （ all P 〈 0. 001 ）. Increased CEA concentrations were signifi- cantly correlated with age 〉 45 years old, postmenopausal, ER - negative, PR - negative, Her - 2 positive （ all P 〈 0.05 ）. Conclusion： Preoperative CEA and CA15 -3 in the early diagnosis of breast cancer were lack of sensi- tivity, CEA and CA15 -3 can be used as important prognostic factors in breast cancer.

关 键 词：乳腺肿瘤 CA15-3 CEA 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]