β-catenin在大肠肿瘤中的表达及其意义  

Expression of β-catenin in human colorectal Adenocarcinoma

作　　者：张丽娟[1] 蔡昕怡[2] 陈云[1] 

机构地区：[1]昆明医科大学第三附属医院(云南省肿瘤医院)病理科,云南昆明650118 [2]昆明医科大学第三附属医院(云南省肿瘤医院)大肠癌中心,云南昆明650118

出　　处：《现代肿瘤医学》2012年第8期1636-1639,共4页Journal of Modern Oncology

基　　金：昆明医学院院内基金(编号:42412-35)

摘　　要：目的:探讨β-连环素(β-catenin)的表达在大肠肿瘤发生发展中的作用及其与临床病理参数之间的关系。方法:应用免疫组织化学SP法检测β-catenin在大肠正常黏膜、大肠腺瘤和大肠腺癌中的表达。结果:β-catenin在正常黏膜中为胞膜表达,腺瘤与腺癌组呈胞浆/核异位表达,异位表达率为10.8%、75.0%、98.2%,三组之间有显著差异(P<0.01)。大肠腺癌中β-catenin蛋白的异常表达随着肿瘤大小、组织学分级、Dukes分期的改变呈逐渐增高趋势,有淋巴结转移者β-catenin蛋白阳性表达率(100.0%)高于无淋巴结转移者(96.4%),但无统计学意义(P>0.05)。结论:β-catenin的异常表达与大肠肿瘤的发生发展有关,是早期事件;β-catenin的异常表达可能与大肠腺癌的恶性行为有关。Objective：To investigate the expression of β-catenin in colorectal carcinomas and their relation with clinical pathological parameters. Methods ： The expression of β- catenin protein was detemined with immunohisto- chemical SP method in the normal mucosa, the adenomas and the adenocarcinoma. Results： β-catenin expression was detected on the cell membrane in normal colorectal mucosa. Cytoplasmic and nuclear expression were detected in the colorectal adenoma and adenocarcinoma. The aberrant expression rates of β- catenin were 10.8% ,75.0% and 98.2%. There were significant difference among these three groups（P 〈0. 01 ）. In carcinoma of intestine the bigger- the tumor size and the higher grade were, the higher the aberrant expression of β- catenin was. Tumors with regional nodal metastasis showed higher abnormal staining rate（ 100.0% ）than those without nodal involvement（96.4% ）. But there was no significant difference（P 〉 0.05 ）. Conclusion with the carcinogenesis development of colorectal carcinoma. in the development of colorectal carcinoma. The aberrant expression of β-catenin may be related The aberrant expression of β- catenin may play a role

关 键 词：大肠肿瘤 Β-连环素 免疫组化 

分 类 号：R735.34[医药卫生—肿瘤]