妊娠合并卵巢恶性肿瘤8例临床分析  

Analysis of 8 pregnant women complicated with malignant ovarian tumor

作　　者：张丹晔[1] 刘水策[1] 刘川[1] 刘大我[1] 刘娟娟[1] 侯锐[1] 林蓓[1] 

机构地区：[1]中国医科大学附属盛京医院妇科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2012年第8期1697-1701,共5页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81172491;81101527);教育部博士点基金(编号:20112104110016);辽宁省教育厅重点实验室项目(编号:2008S247);盛京自由研究者计划(编号:200807);沈阳市科委基金资助项目(编号:F10-14-9-9-52)

摘　　要：目的:分析总结妊娠合并卵巢恶性肿瘤的临床特征及诊治经验。方法:回顾性分析2000年1月至2011年11月中国医科大学附属盛京医院诊断及治疗的8例妊娠合并卵巢恶性肿瘤患者的临床资料。结果:近12年共诊断妊娠合并卵巢恶性肿瘤8例,发病率为0.150/1000次妊娠。上皮性癌共2例(25%),低度恶性肿瘤(交界性上皮性肿瘤和颗粒细胞瘤)共5例(62.5%),生殖细胞肿瘤1例(12.5%)。国际妇产科联盟分期:I期6例(75%),III期2例(25%)。7例(87.5%)行保守性手术治疗(患侧附件切除),其中2例行二次手术。1例(12.5%)病期偏晚(IIIc期),行肿瘤细胞减灭术。随访患者6-104个月,仅1例晚期患者术后2年半死亡,其余均存活至今,生存率87.5%。出生新生儿5例,其中早产窒息死亡1例,其余4例均无后遗症及畸形。结论:妊娠合并卵巢恶性肿瘤的恶性程度偏低,期别偏早,所以应重在早期发现及早期治疗。对于妊娠合并晚期卵巢恶性肿瘤,应及时终止妊娠,行恶性肿瘤的综合治疗。Objective ：To investigate the clinical characteristics, treatment experience of ovarian malignant tumor in pregnancy. Methods： A retrospective analysis was conducted on the clinical data of 8 women with ovarian malignant tumor in pregnancy. Results：The incidence of ovarian malignant tumor in pregnancy was 0. 150/1000 deliveries in the past 12 years. Most of the pathological results were low grade malignant tumors （ n = 5, 62.5% ）, inculding epithelial borderline tumor and granular cell tumor. Two （25%） were diagnosed as ovarian epithelial cancer. One （12.5%） was germ cell tumor. Six （75%） were in stage I （FIGO）. Two （25%） were in stage Ⅲ （FIGO）. Seven （87.5%） were treated by conservative operation, and second ovarian carcinomectomy were performed for two （ 20% ） women. One was treated by reduction - extinction of tumor cells for late stage （Ⅲ c ）- The tumor free survival rate of these 8 women was 87.5% （7 cases） during a follow -up of 6 - 104 months. Totally,5 neonates were born. One premature newborn died from severe asphyxia, and the rest 4 babies were healthy. Conclusion： Ovarian carcinoma has a low ma- lignant grade during pregnancy and mostly are in early stage, so early diagnosis and appropriate treatment are crucial for patients with ovarian cancer diagnosed during pregnancy. For those women in late stage,it seems preferable to con- sider termination of the pregnancy and be performed by comprehensive treatment.

关 键 词：妊娠 卵巢恶性肿瘤 治疗 

分 类 号：R737.31[医药卫生—肿瘤]