癫痫与心肌缺血精神分裂症患者缺血修饰性清蛋白水平对比研究  

Comparative study of ischemia modified albumin levels among patients with epilepsy, myocardial ischemia and schizophrenia

作　　者：吕惠娟 沈琪琳[2] 李平法[3] 周位强[2] 

机构地区：[1]新乡卫生学校,河南新乡453002 [2]新乡医学院第二附属医院 [3]新乡医学院

出　　处：《临床心身疾病杂志》2012年第4期293-295,共3页Journal of Clinical Psychosomatic Diseases

基　　金：河南省科技厅科技计划项目（编号 102102310378）

摘　　要：目的 了解癫痫患者血清缺血修饰性清蛋白水平,为揭示癫痫病患者近期发作状况及并发症的发生机制提供依据.方法 利用人血清清蛋白结合钴间接测定血清缺血修饰性清蛋白,建立自动化检测方法,对28例原发性癫痫病患者、41例急性心肌缺血患者、21例精神分裂症患者及112名健康志愿者进行血清缺血修饰性清蛋白水平检测分析.结果 本研究批内和批间变异系数分别为0.85%和6.70%,诊断的阳性率和特异性可达87.80%和92.50%.对照组游离钴显色率及吸光度与心肌缺血组和癫痫组比较差异有极显著性（P＜0.01）,与精神分裂症组比较差异无显著性（P＞0.05）;心肌缺血组与癫痫病组和精神分裂症组比较差异有极显著性差异（P＜0.01）;癫痫病组与精神分裂症组比较差异有极显著性（P＜0.01）.结论 血清清蛋白结合钴间接测定血清缺血修饰性清蛋白不仅是评价急性心肌缺血非常有价值的生化指标,对癫痫病患者近期发作情况及并发症的早期监测和预防具有重要意义.Objective To explore ischemia modified albumin levels in patients with epilepsy in order to provide basis for revealing patients＇ recent attack status and occurrence mechanisms of complications. Methods Serum ischemia modified albumin levels were indirectly determined utilizing human serum albumin binding cobalt, automation test method was established, and serum ischemia modified albumin levels were detected and analyzed in 28 patients with essential epilepsy, 41 acute myocardial ischemia, 21 schizo- phrenia and 112 healthy volunteers. Results Intra- and inter-assay variation coefficient were respectively 0.85% and 6. 70%. Positive rate and specificity respectively reached 87.80% and 92.50%. Free cobalt coloration rate and ahsorbance had very significant difference in control group from epilepsy group （P〈 0.01） and no from schizophrenia group （P〈0.05） ; there were very significant differences between myo cardial ischemia and epilepsy or schizophrenia group （P〈0.01） ; there were very significant differences between epilepsy and schizophrenia group （P〈0.01）. Conclusion Albumin binding cobalt test indirectly measuring ischemia modified albumin levels are not only valuable biochemical indicator evaluating acute myocardial ischemia, but has significance for monitoring recent attack status and preventing recent attack status and complications of patients with epilepsy early.

关 键 词：原发性癫痫 心肌缺血 精神分裂症 缺血修饰性清蛋白 清蛋白钴结合实验 游离钴显色率 吸光度 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R542.2[医药卫生—临床医学]