脑卒中后抑郁患者认知功能与血脂水平相关性研究  

Correlation study of cognitive function and serum lipid levels in post-stroke depression patients

作　　者：穆俊林[1] 张宁[1] 张朝辉[1] 宋景贵[1] 卢红[1] 赵建明[2] 李静[2] 

机构地区：[1]新乡医学院第二附属医院,河南新乡453002 [2]新乡市中心医院,河南新乡453000

出　　处：《临床心身疾病杂志》2012年第4期296-299,共4页Journal of Clinical Psychosomatic Diseases

基　　金：新乡医学院重点学科资助项目（编号ZD200994）;河南省卫生厅医学科技攻关项目（编号200803083）

摘　　要：目的 探讨脑卒中后抑郁患者认知功能与血脂水平的相关性.方法 将50例脑卒中后抑郁患者设为研究组,48名健康体检者设为对照组,分别进行事件相关电位、探究性眼动分析及血脂水平测定,对两组测定结果进行对比分析,对研究组测定结果进行相关分析.结果 研究组事件相关电位测定异常率为92.0%,N2、P3波潜伏期较对照组延长,P3波幅较对照组显著降低（P＜0.01）;探究性眼动分析测定异常率为96.0%,凝视点数及反应性探索评分均显著低于对照组,而D分值显著高于对照组（P＜0.01）.研究组血清胆固醇水平显著高于对照组（t=2.89,P＜0.01）,而血清三酰甘油、高密度脂蛋白、低密度脂蛋白与对照组差异均无显著性（P＞0.05）.研究组血清胆固醇水平与事件相关电位N2、P3波潜伏期及探究性眼动分析D值均呈显著正相关（P＜0.01）;而与事件相关电位P3波幅及探究性眼动分析凝视点数和反应性探索评分均呈显著负相关（P＜0.01）.结论 脑卒中后抑郁患者存在明显的认知功能损害和血清胆固醇水平增高,且血清胆固醇水平越高,患者认知功能障碍越严重.Objective To explore the correlation between cognitive function and serum lipid levels in post stroke depression （PSD） patients. Methods Fifty PSD patients were assigned to research group and 48 healthy physical examinees to control group, event related potential （ERP）, exploratory eye movement （EEM） and serum lipid levels determined, determination results of two groups contrastively analyzed, and those of research group correlatively analyzed. Results In research group the abnormal rate of ERP was 92.0Y00, N2 and P3 latency prolonged, and Pa amplitude lowered more significantly compared with control group （P〈0.01）; in research group the abnormal rate of EEM was 96.0%, the number of eye fixation （NEF） and the responsive search score （RSS）were significantly lower, and D score was significantly higher compared with control group （P〈0.01）. Serum cholesterol levels were significantly higher in research than in control group （t= 2.89, P〈0.01）, but there were no significant differences in triacylglycerol, high and low density lipoprotein （P〈0.05）. Serum cholesterol levels were significantly positively related to N2 and P3 latency as well as D score （P〈0.01） and negatively to P3 amplitude, NEF and RSS （P〈0.01） in research group. Conclusion PSD patients have significant cognitive dysfunction and elevated serum cholesterol, and the higher the level of serum cholesterol is, the severer cognitive dysfunction becomes.

关 键 词：脑卒中后抑郁 认知功能 血脂 事件相关电位 探究性眼动分析 

分 类 号：R743[医药卫生—神经病学与精神病学]