美施康定、路泰对重度癌痛的止痛治疗  

THE ANALGESIC EFFECT OF MS CONTIN, SRM RHOTARD FOR SEVERE CANCER PAIN IN 145 PATIENTS

作　　者：李平[1] 郭良君[1] 郑坚[1] 廖倚萍[1] 李丽莎[1] 

机构地区：[1]暨南大学医学院附一院肿瘤科,广州510630

出　　处：《中国疼痛医学杂志》2000年第1期31-35,共5页Chinese Journal of Pain Medicine

摘　　要：目的 :观察美施康定、路泰对重度癌痛的止痛效果及对患者生活质量的影响。方法 :1 45例经病理证实的中晚期重度癌痛病人 ,83例服用美施康定 (A组 ) ,6 2例服用路泰 (B组 ) ,初始剂量均为 30mg口服 ,每 1 2h一次 ;据实际疗效来调整用量 ,每次递增 30mg ,直到达到满意的止痛效果。结果 :美施康定、路泰的镇痛有效率分别为 :95 .2 % ,93.5 %。完全缓解率分别为 81 .9% ,80 .6 %。镇痛有效时间分别为 :9.1±4.1h ,8.7± 4.4h。两药镇痛效果及镇痛有效时间经统计学处理无显著性差异 (P >0 .0 5 )。治疗后分别有 6 2人 ( 74.7% ) ,47人 ( 75 .8% )生活质量较前提高一个等级 ,治疗前后患者生活质量存在着显著性差异 (P <0 .0 1 )。两药对骨痛、内脏痛、软组织浸润痛效果好 ,对神经痛效果欠佳。神经痛与其它类型疼痛的镇痛效果存在着显著性差异 (P <0 .0 1 )。两药的主要不良反应均为便秘 ,恶心、呕吐、嗜睡、排尿困难等。结论 :美施康定或路泰对重度癌痛止痛效果好 ,镇痛时间长 ,副作用小 ,改善了患者的生活质量 。Aim:To evaluate the analgesic effect of MS Contin and SRM-Rhotard for severe cancer pain and improving quality of life for patients. Methods: There were 145 cases histopathologically proven mid and advanced cancer patients (pts) with severe pain. 83 pts were treated with Ms Contin (group A), 62 pts with SRM Rhotard (group B). Their initial dosage in group A and B were 30mg/12hours. According to effect of pain relief, an increament of 30mg /12hours was given to remit pain effectively. Result: The effective rate of MS Contin and SRM Rhoard was 95.2% and 93.5%, respectively. Complete remission rate was 81.9% and 80.6% respectively, duration of pain relief 9.1±4.1h and 8.7±4.4h. The results showed that MS Contine has a similar analgestic effect and duration with SRM Rhotard (P>0.05). Life quality was elevated for one grade in 62 and 47 pts after treatment. There were significant difference in life quality after treatment (P<0.01). The pain relief in patients with osteocope, visceral pain, soft tissue infiltrative pain were better than neurological pain. There were significant difference between neuralgia and other types of pain (P<0.01). The main aversive side effects of MS Contin or SRM Rhotard were constipation, nausea, vomiting, somnolence, retention of urine, et al. Concusion: MS Contin and SRM Rhotard could effectively remit severe cancer pain, with long duration of pain relief, and rather weak side effects resulting in significant improvement of patients quality of life. It could be the first choice in the control of severe cancer pain.

关 键 词：路秦 癌症 止痛 美施康定 

分 类 号：R730.5[医药卫生—肿瘤]