东莞部分地区感染性腹泻致病菌的培养结果及耐药性分析  

Distribution and resistance of infectious diarrheal pathogenic bacteria in Dongguan area

作　　者：郭主声[1] 张丽华[1] 林偲思[1] 张丽[1] 朱学海[1] 

机构地区：[1]中山大学附属东莞东华医院检验科细菌室,广东省东莞市523110

出　　处：《中国医药》2012年第8期992-994,共3页China Medicine

基　　金：基金项目：全球沙门菌监测网资助项目（GSS）;中美新发和再发,传染病合作计划资助项目（1U2GGH000018-01）

摘　　要：目的探讨东莞部分地区引起感染性腹泻致原菌分布及耐药状况，为本地区流行病学研究及临床合理用药提供依据。方法收集2001年1月至2009年12月中山大学附属东华医院住院部和门急诊的5939份腹泻患者的粪便标本进行微生物培养、鉴定及药敏试验，并加以比较分析。结果5939份粪便标本中，共检出致病菌369株，阳性分离率为6．2％，其中分离出志贺菌属118株（32．0％）、沙门菌属115株（31．2％），致病性大肠杆菌81株（21．9％）、弧菌属24株（6．5％）、单胞菌属19株（5．2％）、金黄色葡萄球菌10株（2．7％）及耶氏菌属2株（0．5％）。挑选11种抗菌药物进行体外敏感试验，各菌属对抗生素的敏感性有差异，对复方新诺明及氨苄西林耐药率较高，但对第三代头孢有较强的敏感性。结论东莞地区感染性腹泻的致病菌种类多，且耐药性不同，主要以志贺菌属和沙门菌属为主，应根据微生物鉴定及药敏试验结果指导临床合理使用抗生素，以提高治疗效果。Objective To investigate the consitutes and resistance of bacterial pathogens isolated from diarrheal patients in Dongguan area, and to offer the data for guiding epidemiological study and clinical treatment. Methods A total of 5939 stool samples were collected from inpatient department and outpatients in Dongguan hospital between 1 st January 2001 and 31 st December 2009. They underwent bacteriological culture, identification, antibiotic sensitive test, and comparative analysis. Results In 5939 cases of patients with diarrhea stool samples, a total of 369 was detected and the positive isdootion rate was 6.2%. The percentage of Shigella, Salmonella, enteropathogenie E. coli, Vibrio, Pseudoalteromonas, Staphylococcus aureus and Yersinia isolated from these 369 samples was 31.9% ,31.2% and 21.9% ,6.5% ,5.2% ,2.7% and 0.5%. The sensitivity test of 12 antibavterial drugs were calculated and showed a high rate of drug-resistance to SXT and AMP, but they were susceptible to the third Cephems. Conclusions There are many species and serotype of pathogenic bacteria causing the infective diarrhea in the part of Dongguan area. Shigella and Salmonella are the main causes with a different rate of drug resistance. Antibiotic should be used reasonably with the susceptibility of the pathogen to improve the clinical therapeutic effect.

关 键 词：感染性腹泻 致病菌 抗生素 耐药性 

分 类 号：R574[医药卫生—消化系统]