利培酮口服液合并丙戊酸钠缓释片治疗老年躁狂症疗效观察  

The efficacy risperidone oral solution combined with sodium valproate sustained release tablets in treatment of senile mania

作　　者：宗宝玉[1] 陈铁光[1] 

机构地区：[1]北京市大兴区精神病医院老年病科,北京102600

出　　处：《蚌埠医学院学报》2012年第7期848-849,862,共3页Journal of Bengbu Medical College

摘　　要：目的:观察利培酮口服液合并丙戊酸钠缓释片治疗老年躁狂症的临床疗效及安全性。方法:采取随机入组,将70例老年躁狂症患者分为2组,观察组采用利培酮口服液合并丙戊酸缓释片治疗,对照组采用单一丙戊酸钠缓释片治疗,观察治疗6周,用躁狂量表(BRMS)评定疗效,不良反应量表(TESS)评定不良反应,并进行对比分析。结果:2组BRMS评分治疗前后差异无统计学意义(P>0.05),观察组治疗后1～6周末BRMS评分均下降,明显优于对照组(P<0.01);观察组6周末总有效率88.57%,对照组80.00%,差异无统计学意义(P>0.05)。结论:利培酮口服液合并丙戊酸钠缓释片治疗老年躁狂症起效快,疗效肯定,不良反应少,药物依从性好,适合于老年人群。Objective：To observe the clinical curative effect and safety of risperidone oral solution combined with sodium valproate sustained release tablets in the treatment of senile mania. Methods： Seventy cases of senile mania were adopted randomly into two groups,the patients in the observation group were treated with risperidone oral solution combined with sodium valproate sustained release tablets, others in the control group were treated with sodium valproate sustained release tablets only, all patients were observed for 6 weeks. Mania Rating Scale （BRMS） was used to evaluate the curative effect, and treatment emergent symptom scale （TESS） was used to evaluate adverse reactions, all results were compared and analyzed. Results：The socres of BRMS in the two groups were not different before treatment（ P 〉 0.05 ）. In observation group, BRMS scores at every weekend were decreased,which were better than in control group significantly（ P 〈 0.01 ） ,the total efficiency of 6 weeks was 88.57% in observation group, and 80.00% in control group, there was no statistical difference （ P 〉 0.05 ）. Conclusions ： In the treatment of senile mania, risperidone oral solution combined with sodium valproate sustained release tablets has a fast onset of action and a good efficacy, fewer adverse reaction. Drug compliance is good, and suitable for aged person.

关 键 词：躁狂症 利培酮 丙戊酸钠 老年医学 

分 类 号：R749.41[医药卫生—神经病学与精神病学]