多领域认知训练对社区轻度认知障碍老年人影响的随机对照研究  被引量:25

A randomized controlled trial of multi-domain cognitive training for community older adults with mild cognitive impairment

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作  者:成燕[1] 冯威[1] 张旭[1] 申远[1] 李清伟[1] 李春波[2] 吴文源[1] 

机构地区:[1]同济大学附属同济医院心身科,上海200065 [2]上海交通大学附属精神卫生中心

出  处:《中华精神科杂志》2012年第4期228-231,共4页Chinese Journal of Psychiatry

基  金:国家科技支撑计划(2009BA177803)

摘  要:目的探索多领域认知训练对礼区轻度认知障碍(MCI)老年人的十预效果。方法将120例研究对象按照区组随机化方法分为干预组(60例)和对照组(60例),干预组进行12周多领域认知训练,2次/周,60min/次;干预前后采用可重复的成套神经心理状态测量(RBANS)、视觉匹配与推理测验、stroop字色干扰测验(CWST)、彩色数字连线测验(TMT)评定2组的认知功能并进行比较。结果(1)干预前:十预组RBANS注意力因子分[(81.3±15.5)分]与对照组[(74.3±12.1)分]比较,差异有统计学意义(t=-2.37,P=0.02);其他测评指标2组比较差异均无统计学意义。(2)干预后:十预组与对照组RBANS总分[(86.4±12.6)分:(78.6±9.3)分;t=3.07,P=0.00]、即刻记忆[(83.4±14.1)分:(74.6±11.5)分;t=3.03,P=0.00]、空间结构[(95.7±14.3)分:(89.1±12.9)分;t=2.16,P=0.03]、延迟记忆等因子分[(91.8±17.4)分:(83.7±13.0)分;t=2.32,P=0.02],视觉匹配与推理[(5.2±1.9)分:(3.94-1.9)分;t=3.11,P=0.00],TMT测验1完成时间[(110.0±44.4)s:(130.5±45.1)S;t=-2.07,P=0.04]比较,差异有统计学意义。结论多领域认知训练干预效果明显,依从性好,对社区MCI老年人的认知功能具有促进或保持作用。Objective To explore the effect of multi-domain cognitive training intervention amongst older adults with mild cognitive impairment (MCI). Methods One hundred and twenty participants were randomly allocated to intervention group (60 subjects) and control group (60 subjects). The intervention consists of twenty-four 60-minute sessions delivered twice per week over a period of 12 weeks. Outcomes were assessed by Repeatable Batter7 for the Assessment of Neuropsychological Status (RBANS) , Visual Reasoning Test, Color Word Stroop Test (CWST) and Trail Making Test (TMT), and collected at baseline and immediate 'after intervention. Results ( 1 ) No significant group difference was found except attention index of the RBANS ( intervention group 81.3 ± 15.5, control group 74. 3 ± 12. 1, t = - 2. 37, P = 0. 02) at baseline. (2) Most outcomes showed significant group differences after intervention, including RBANS total score ( intervention group 86.4 ± 12. 6, control group 78.6 ±9.3, t = 3.07, P =0. 00), immediate memory (intervention group 83.4 ± 14. 1, control group 74. 6 e 11.5, t = 3.03, P = 0. 00 ) , delayed memol7 (intervention group 91.8 ± 17.4, control group 83.7 ± 13.0, t = 2. 32, P = 0. 02) , and visuo-spatial/ constructional ( intervention group 95.7 ± 14. 3, control group 89.1 ± 12. 9, t = 2. 16, P = 0. 03) indices of RBANS, the ,visual reasoning test (intervention group 5.2 ± 1.9, control group 3.9 ± 1.9, t = 3.11, P = 0. 00) and completing time of TMT A ( intervention group 110. 0 ±44.4, control group 130. 5 ±45. 1, t = - 2. 07, P = 0. 04). Conclusions Multi-domain cognitive training intervention could effectively improve or maintain cognition of community older adults with MCI.

关 键 词:认知疗法 衰老 轻度认知障碍 

分 类 号:R749.1[医药卫生—神经病学与精神病学]

 

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