兔视神经损伤后盐酸美金刚的保护作用  

Rabbit after optic nerve injury protective effects of memantine hydrochloride

作　　者：胡丽荣[1] 王景春[2] 张俊奇[1] 王权力[1] 肖倩[1] 李金明[1] 

机构地区：[1]河北联合大学附属医院眼科,河北唐山063000 [2]唐山市丰润区人民医院

出　　处：《河北联合大学学报（医学版）》2012年第4期464-465,共2页Journal of North China Coal Medical College

基　　金：河北省科学技术研究与发展计划项目基金资助(编号:10276105 D-17)

摘　　要：①目的探讨盐酸美金刚对兔受损视神经的保护作用。②方法取健康大白兔54只,随机分为3组,对照组A组18只,损伤组B组18只,损伤治疗组C组18只。B、C 2组兔子双眼作视神经损伤模型后,C组给予盐酸美金刚药物治疗,剂量每只兔子10mg/d,每日上午一次性给全部药物。B组给予生理盐水。分别于造模后第1、3、7、14、21、28天随机处死A、B、C组各3只兔子,检测视网膜谷氨酸浓度变化。③结果视神经损伤后谷氨酸浓度迅速增高。④结论损伤治疗组谷氨酸浓度明显低于损伤组,且差异显著。Objective To study the protective effects of memantine hydrochloride on damaged optic nerve in rabbits. Methods 54 healthy rabbits were randomly divided into 3 groups, control group （group A） 18, injured group （group B） 24,injury treatment group（ group C） 24,B, C for two rabbit eyes after optic nerve injury model, C group received memantine hydrochloride drug treatment, each rabbit daily dose of 10mg, once daily morning to all drugs. Group B received normal saline. Respectively, three rabbits in group A, group B1 and group C1 were randomly killed after modeling 1,3,7,14,21,28 days to detect changes in retinal concentrations of glutamate. Results The optic nerve glutamate concentration increased rapidly after injury. Conclusion The treatment group were significantly lower than glutamate injury group, and the difference is remarkable.

关 键 词：盐酸美金刚 谷氨酸 兴奋毒性 视网膜 

分 类 号：R774.6[医药卫生—眼科]