P-选择素对Apc^(Min/+)小鼠肠道肿瘤的作用  

Role of P-selectin in intestinal tumorigenesis in Apc^(Min/+) mice

作　　者：郭四美[1] 亓翠玲[1] 叶杰[1] 周秦[1] 王丽京[1] 

机构地区：[1]广东药学院血管生物学研究所,广东广州510006

出　　处：《中国病理生理杂志》2012年第7期1197-1201,共5页Chinese Journal of Pathophysiology

基　　金：科技部"973"项目国家重点基础研究发展计划(No.2010CB529702);国家青年基金资助项目(No.30900764)

摘　　要：目的:研究P-选择素(P-selectin)在ApcMin/+小鼠肠道肿瘤中的作用。方法:采用P-selectin基因缺失的基因工程小鼠和肠道肿瘤模型ApcMin/+小鼠杂交,计数ApcMin/+小鼠与ApcMin/+P-selectin-/-杂交小鼠小肠及大肠肿瘤的数目,并测量其肿瘤体积,研究P-selectin对ApcMin/+小鼠肠道肿瘤的作用。结果:与ApcMin/+小鼠相比,ApcMin/+P-selectin-/-杂交小鼠在9周龄时肠道肿瘤数目与总负荷明显减少。结论:P-selectin缺失能够显著抑制ApcMin/+小鼠肠道肿瘤的生长。AIM： To investigate the role of P- selectin in intestinal tumorigenesis in Apc^Min/＋ mice （ C57BL/ 6J-Apc^Min/＋/J）. METHODS： Female P- selectin knockout mice （]36. 129S7 -Selp^tmlBay/J, that was P- selectin-/-） were mated with male Apc^Min/＋ mice. The offspring was genotyped for Min＋/- and P-selectin null mutantions, which were Apc^Min/＋ P - selectin-/- mice. The tumor number and gross tumor volume in the small and large intestines of theApc^Min/＋＋ P-selectin-/- mice and Apc^Min/＋ mice were determined. REULTS： P -seleetin deficiency in Apc^Min/＋ mice resulted in significant decreases in the tumor number and gross tumor volume in the small intestine and total intestine. CONCLU- SION： Deletion of P -selectin significantly inhibits the tumorigenesis in mouse intestines. In addition, the results also sug- gest that P - selectin may be a marker for colon cancer.

关 键 词：P-选择素 基因工程小鼠 肠道肿瘤 

分 类 号：R363.2[医药卫生—病理学] R735.3[医药卫生—基础医学]