脑数字减影血管造影术对血浆ET-1和vWF水平的影响  

Changes of plasma endothelin-1 and von Willebrand factor in patients undergoing cerebral digital substration angiography

作　　者：付棉[1] 秦超[1] 程道宾[1] 赵伟佳[1] 梁志坚[1] 刘竞丽[1] 梁明辉[1] 陈相任[1] 

机构地区：[1]广西医科大学第一附属医院神经内科,广西南宁530021

出　　处：《中国病理生理杂志》2012年第7期1323-1325,共3页Chinese Journal of Pathophysiology

基　　金：广西科学研究与技术开发计划项目(No.桂科攻0322025-8)

摘　　要：目的:探讨脑数字减影血管造影术(DSA)对血浆内皮素-1(ET-1)及von Willebrand因子(vWF)的水平的影响。方法:用ELISA法测定连续收集的108例缺血性脑血管病患者脑DSA术前、术后即刻、术后24 h血浆ET-1和vWF的含量。结果:患者脑DSA后血浆ET-1水平均明显升高,ET-1在术后即刻有明显升高,为(550.19±108.06)ng/L),术后24 h有所下降,为(517.26±111.84)ng/L,但仍高于术前水平[(501.20±111.86)ng/L],3个时点血浆ET-1水平有明显差异。血浆vWF水平术后未观察到明显升高。结论:术后ET-1的持续升高提示脑DSA可能对血管内皮细胞造成一定程度的损伤。AIM： To investigate the effects of cerebral digital substration angiography（DSA） on the expression of endothelin- 1 （ET- 1 ） and van Willebrand factor（vWF） in vascular endothelial cells from the patients with ischemic eerebrovascular disease. METHODS： The plasma levels of ET - 1 and vWF were measured by enzyme - linked immu- nosorbent assay in 108 patients before, immediately and 24 h after cerebral DSA. RESULTS： The plasma level of endo- thelin - 1 significantly increased immediately [ （ 550. 19 ± 108.06） ng/L ] and 24 h [ （ 517.26 ±111.84） ng/L ] after cere- bral DSA as compared with that before the procedure [ （501.20± 111.86 ） ng/L ] （P 〈 0.05 ）. The level of vWF was not changed before and after operation. CONCLUSION ： The marked and sustained increase in endothelin - 1 plasma level af- ter cerebral DSA is probably related to mechanical endothelial injury by the procedure of cerebral DSA.

关 键 词：血管造影术 数字减影 内皮缩血管肽-1 von WILLEBRAND因子 

分 类 号：R363[医药卫生—病理学]