MUC1、MUC2在宫颈癌中的表达及其临床意义  

The expressions of MUC1 and MUC2 in the Cervical squamou Cell Cancer and its clinical significance

作　　者：张继红[1] 任立群[2] 王彩芹[1] 姜晶[1] 宓淑芳[1] 王红[1] 历春[3] 李西宁[2] 温春阳[3] 

机构地区：[1]北华大学附属医院,吉林吉林132011 [2]吉林大学药学院,吉林长春130021 [3]北华大学医学部,吉林吉林132013

出　　处：《中国实验诊断学》2012年第7期1227-1230,共4页Chinese Journal of Laboratory Diagnosis

基　　金：吉林市科技计划项目(编号:2008038)

摘　　要：目的探讨MUC1、MUC2两种粘蛋白在宫颈鳞状细胞癌中的表达及其临床意义。方法 30例宫颈鳞状细胞癌的组织样本(实验组)和10例轻度慢性宫颈炎的组织标本(对照组),应用免疫组织化学及Western blot技术检测组织内MUC1、MUC2两种粘蛋白在宫颈鳞状细胞癌中的表达。结果 MUC1蛋白在宫颈鳞状细胞癌中的表达明显高于对照组(P<0.05),且浸润深度>3mm的癌组织的表达明显高于浸润深度≤3mm(P<0.05);而与发病人群的年龄、浸润范围、宫颈癌组织的分化及有无淋巴结转移无明显相关性;MUC2蛋白在宫颈鳞状细胞癌中无明显表达。结论 MUC1蛋白与子宫颈鳞状细胞癌的发生发展有关。Objective To investigate MUC1,MUC2 two kinds of mucin in the cervical squamous cell carcinoma and its clinical significance.Methods 30 patients with cervical squamous cell carcinoma tissue samples（experimental group） and 10 patients with mild chronic cervicitis tissue samples（control group）.We used immunohistochemistry and Western blot detection of tissue MUC1,MUC2 two kinds of mucin in cervical squamous cell carcinoma.Results MUC1 protein in cervical squamous cell carcinoma was significantly higher（P0.05） than control group,and depth of invasion3 mm of the cancer tissue was significantly higher than the depth of invasion≤3 mm（P0.05）;while independent of the incidence of people with age,the scope of infiltration,differentiated squamous cell carcinoma and lymph node metastasis;MUC2 protein in cervical squamous cell carcinoma,no significant expression.Conclusion The MUC1 protein has relation of cervical squamous cell carcinoma＇s occurrence and development.

关 键 词：MUC1 MUC2 宫颈鳞状细胞癌 

分 类 号：R737.33[医药卫生—肿瘤]