STAT3蛋白、VEGF和MVD在肾上腺皮质癌中的表达及其意义  

Expressions of STAT 3,VEGF and MVD and the significance in adrenal cortical carcinoma

作　　者：祝宇[1] 盛佳雁[1] 徐云泽[1] 吴瑜璇[1] 赵菊平[1] 何竑超[1] 袁菲[2] 芮文斌[1] 张翀宇[1] 计骏[3] 孙福康[1] 周文龙[1] 谢欣[1] 沈周俊[1] 金晓龙[2] 

机构地区：[1]上海交通大学医学院附属瑞金医院泌尿外科,上海200025 [2]上海交通大学医学院附属瑞金医院病理科,上海200025 [3]上海交通大学医学院附属瑞金医院普外科,上海200025

出　　处：《现代泌尿外科杂志》2012年第4期347-349,共3页Journal of Modern Urology

基　　金：上海市自然科学基金资助(No.09ZR1418500);上海市教委科技创新项目(No.11YZ58)

摘　　要：目的探讨信号转导和转录活化因子3(signal transducers and activators of transcription 3,STAT3)、血管内皮生长因子(vascular endothelial growth factor,VEGF)和微血管密度(microvessel density,MVD)在肾上腺皮质癌(ACC)中的表达及其临床意义。方法选取经手术治疗且具有完整的临床、病理资料的肾上腺皮质肿瘤存档石蜡标本37例,其中良性组20例,恶性组(ACC组)17例。采用免疫组化技术,检测良、恶性肾上腺皮质肿瘤中STAT3、VEGF和MVD的表达情况。结果 STAT3在ACC组中呈高表达(11/17,64.71%),在良性组中表达较低(4/20,20%),ACC组与良性组之间STAT3的表达有显著性差异(P<0.05);VEGF在ACC组中呈高表达(12/17,70.59%),在良性组中表达较低(5/20,25%),VEGF在ACC组中的表达与在良性组中的表达有显著性差异(P<0.05);MVD在ACC组中的表达为76.40±15.64,良性组中为21.05±8.07,两者之间有显著性差异(P<0.05)。无论是在良性组中还是在ACC组中,STAT3与VEGF的表达、VEGF与MVD的表达均呈正相关。结论 STAT3和VEGF在ACC中的高表达为抗肿瘤血管生成治疗在ACC中的应用,提供了一定的理论依据。Objective To investigate the expressions of signal transducers and activators of transcription 3（STAT3）,vascular endothelial growth factor（VEGF） and microvessel density（MVD） in adrenal cortical carcinoma（ACC） and to discuss their clinical significance.Methods 37 adrenal cortical neoplasm specimens were divided into two groups,20 in the benign group and 17 in the malignant group（adrenal cortical carcinoma,ACC group）.The expressions of STAT3,VEGF and MVD were detected with immunohistochemical staining.Results STAT3 was highly expressed in the ACC group（11/17,64.71%）,while lowly expressed in the benign group（4/20,20.00%）,with significant difference（P〈0.05）.VEGF staining was seen in 70.59%（12/17） of the malignant cases versus 25.00%（5/20） of the benign cases,with significant difference（P〈0.01）.MVD was highly expressed in the ACC group than in the benign group（76.40±15.64 vs.21.05±8.07）,with significant difference（P〈0.05）.In both benign and malignant adrenal neoplasm,STAT3 expression was positively correlated with VEGF expression,which was positively correlated with MVD.Conclusion The high expression of STAT3 and VEGF in ACC contributes to tumor angiogenesis.

关 键 词：肾上腺皮质癌 信号转导和转录活化因子3(STAT3) 血管内皮生长因子 微血管密度 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]