中氮茚类羧酸化合物的合成及抑菌活性  

Synthesis and Antibacterial Activities of Some Indolizine Carboxylic Acids

作　　者：江玉亮[1] 徐助雄[1] 王炳祥[1] 

机构地区：[1]江苏省生物功能材料重点实验室江苏省生物医药功能材料工程研究中心南京师范大学化学与材料科学学院,南京210097

出　　处：《高等学校化学学报》2012年第8期1718-1721,共4页Chemical Journal of Chinese Universities

基　　金：江苏省自然科学基金(批准号:BK2008435);江苏省高校优势学科建设工程资助项目资助

摘　　要：合成了8个中氮茚类羧酸化合物,产物经红外、核磁、质谱及元素分析表征,并研究了其抑菌性能.结果表明,化合物3a,3c,5a,5c和5d对大肠杆菌有一定抑制作用,化合物3a和3c对金黄色葡萄球菌有抑制作用.其中化合物3c对所选2个菌种均表现出较好的抑菌性能.A new procedure for the synthesis of indolizine carboxylic acids were developed. In the presence of tetrakispyridinecobalt（ II ） dichromate （TPCD）, indolizine carboxylic acid esters were readily synthesized by a one-pot reaction sequence which consists of a 1,3-dipolar cycloaddition of pyridinium N-ylides to alkenes, followed by an aromatization. Eigth indolizine carboxylic acids 3a-3c and 5a--5e were obtained in good yields by the direct hydrolysis of the crude indolizine carboxylic acid esters, and characterized by IR, 1H NMR, MS and elemental analysis. The study on the antibacterial activity of these compounds against esche- richia coli and staphylococcus aureus indicated that compounds 3a, 3c, 5a, 5c and 5d had a certain inhibitory effect on escherichia coli, while compounds 3a and 3c showed some inhibitory effect on staphylococcus aureus. Compound 3c showed good antimicrobial properties on these two strains.

关 键 词：中氮茚类羧酸化合物 抑制作用 抑菌性 

分 类 号：O629[理学—有机化学]