改进累积logistic回归对阿尔茨海默病伴抑郁患者影响因素研究  

Related factors on patients with depression related to Alzheimer＇s disease based on the improved cumulative logistic regression

作　　者：罗艳虹[1] 郭志新[2] 王瑾瑶[1] 艾永梅[1] 陈培翠 余红梅[1] 

机构地区：[1]山西医科大学卫生统计学教研室,太原030001 [2]山西医科大学第二医院内分泌科

出　　处：《中华流行病学杂志》2012年第8期788-791,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金（30972545）;山西省留学回国人员科研启动基金（2011-048）;山西医科大学青年基金（02200916）

摘　　要：目的了解阿尔茨海默病（AD）伴抑郁症患者的影响因素。方法采用老年抑郁量表评价AD患者的抑郁程度，采用改进累积logistic回归对AD伴抑郁症患者的影响因素进行分析。结果抽样调查AD患者196例，年龄58—89（72.3±6．0）岁；男性60例（30．6％），女性136例（69．4％）。改进累积logistic回归结果表明，体育活动、糖尿病、MoCA值、听力、经济来源、是否饮酒与AD患者抑郁程度有关（P值均〈0．10），“正常”与“轻度抑郁”之间的间距比“轻度抑郁”与“中重度抑郁”之间的间距小。结论轻度抑郁患者是防治的重点，AD伴抑郁症患者的影响因素是多方面的。Objective To explore the determinants of Alzheimer＇ s disease （AD） patients with depression. Methods The degree of depression on AD patients was assessed by the geriatric depression scale. Improved cumulative logistic regression （ICLR） was used to analyze the determinants of AD patients with depression. Results 196 AD patients were investigated. Among the 196 AD patients, there were 60 （30.6%） males and 136 （69.4%） females, at 58-89 years of age （72.3 ~ 6.0）. Physical activity, diabetes, MoCA, hearing, economic sources and alcohol were related to the degree of depression of AD patients （P〈0.10）. The difference between ＂normal＂ and ＂mild depression＂ was smaller than difference between ＂mild depression＂ and ＂severe depression＂. Conclusion AD patients with mild depression were the target population for prevention and they were influenced by several factors listed above.

关 键 词：阿尔茨海默病 抑郁症 改进累积logistic回归 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]