体检人群非酒精性脂肪性肝病检出率及其相关因素分析  

Prevalence and risk factors of non-alcoholic fatty liver disease in checked-up individuals

作　　者：王春霞[1] 麦韵屏[1] 沙卫红[1] 王启仪[1] 

机构地区：[1]广东省人民医院/广东省医学科学院消化内科,广州市510080

出　　处：《实用肝脏病杂志》2012年第4期289-290,共2页Journal of Practical Hepatology

基　　金：广东省科技计划项目资助(00080711120302025)

摘　　要：目的探讨广东地区不同年龄段体检人群非酒精性脂肪性肝病（NAFLD）患病率及相关因素。方法对20047例体检人群进行B超和血生化学检查。结果本组体检人群NAFLD检出率为13.2%,其中单纯性非酒精性脂肪肝检出率为8.7%（1731/20047）,非酒精性脂肪性肝炎为4.5%（910/20047）,未检出肝硬化和肝癌;随年龄增长,NAFLD检出率逐渐增高,其中60～70岁年龄组人群检出率为25.6%,50～60岁年龄组为23.8%,与小于30岁组、30-岁组、40-岁组和70-岁组比,差异有统计学意义（分别为4.7%、10.8%、17.6%和18.7%,P〈0.01）;男性人群NAFLD检出率高于女性（18.8%对7.8%,P〈0.01）,但在60岁以上人群,男性与女性NAFLD检出率无明显差别（22.1%对22.4%,P=0.883）;NAFLD患者合并高血压、高血糖、高甘油三酯血症和高胆固醇血症的发生率均高于无NAFLD人群（35.2%对11.7%,14.4%对2.6%,46.8%对10.1%,31.8%对2.5%,P〈0.01）。结论 NAFLD的发病与年龄、性别及高血压、高血糖、高甘油三酯血症和高胆固醇血症等因素相关。Objective The aims of this study was to investigate the prevalence and risk factors of nonalcoholic fatty liver disease （NAFLD）in checked-up subjects in Guangdong Province. Methods 20047 subjects were checked-up by ultrasound and blood parameters. Results The prevalence of NAFLD in this subjects was 13.2% ,in which the prevalence of NAFLD in male subjects was significantly higher than that in the female subjects （18.8% vs 7.8%,P〈0.01）;the peak prevalence （23.8% to 25.6%） occurred in persons of 50- to 69-year old age,which were obviously higher than those in the other groups （4.7% in younger than 30,10.8% in younger than 40,17.6% in younger than 50 and 18.7% in older than 79 years of age,P〈0.01）;Individuals with hypertension,hyperlipidemia and hyperglycemia had higher prevalence of NAFLD than those without （31.3% vs. 10.0%,41.3% vs. 8.2%,and 27.9% vs. 10.6%,P〈0.01）. Conclusions The prevalence of NAFLD is high in Guangdong Province and there is a closed correlation of NAFLD to hypertension, hyperlipidemia and hyperglycemia.

关 键 词：非酒精性脂肪性肝病 高血压 高血糖 高血脂 体检人群 

分 类 号：R575.5[医药卫生—消化系统]