近交系C57BL/6J小鼠的脱毛特征  

The features of hair loss in the inbred strain of C57BL/6J

作　　者：黄月玲[1] 戴丽军[1] 谭小军[1,2] 任韵[1,3] 叶炳飞[1] 朴金松[1,2] 高蔚樱[1,2] 劳淑贞[1,2] 周敏仪[1,3] 侯敏[1,2] 

机构地区：[1]广州医学院实验动物中心,广东广州510182 [2]广州医学院附属肿瘤医院病理科,广州510095 [3]广州医学院附属肿瘤医院,肿瘤研究所,广州510095

出　　处：《解剖学研究》2012年第4期267-271,共5页Anatomy Research

基　　金：广州医学院博士启动基金(2010C32);广州医学院附属肿瘤医院重大专项基金(2010-yz-02)

摘　　要：目的了解近交系C57BL/6J小鼠脱毛的性质和脱毛的特征。方法在各代鼠详细观察记录脱毛出现的时间、状况和缓解情况;利用对照组2对来自不同父母鼠的F1雌雄鼠进行交配实验和回盒饲养实验,观察脱毛和脱毛缓解的特征,在F2小鼠观察脱毛特征的遗传性,对脱毛区域皮肤进行病理分析。结果脱毛(头、颈或背部)多出现在3～6只同养的雌性鼠中(对照组32.4%,实验组16.3%),脱毛-新毛生长的过程交替进行,交配有缓解脱毛的作用并能维持新毛的生长状态,脱毛的特征可以遗传。皮肤病理显示皮肤各层结构、毛囊和毛囊球上皮无明显病理性改变。结论脱毛可能是本品系在特定饲养条件下适应环境压力失败及缺乏生理活动的一种表现,具有经过良性、可缓解、特征可遗传等特点。Objective To characterize the nature and features of hair loss in the inbred strain C57BL/6J. Methods The development, manifestations and improving conditions of hair loss were closely observed and recorded in each generation. Two pairs of F1 female and male offspring that came from two different parental mice were used to mate in order to determine if hair loss would im- prove and at the same time to confirm if the features of hair loss would pass onto the F2 generation. After mating, the females contin- ued to live with their corresponding sisters in the same cage so as to observe if hair loss would re-occur. The skin with hair loss was processed for pathologic examination. Results Hair loss most frequently developed spontaneously on the head, neck and dorsal areas in female mice that 3 to 6 lived together in the same cage （control group： 32.4%, experimental group： 16.3%）. The process of hair loss-hair growth alternated constantly. Hair loss was significantly alleviated by mating, and mating could sustain the growth of hairs that re-grown after loss. The features of hair loss could pass onto the next generation. The skin histology showed that there were little pathologic changes in each layer of the skin, follicles and hair follicles. Conclusion Under a specific living condition, hair loss de- veloped in the C57BL/6J mice, mainly in the females, might be a manifestation of their failure in adaptation, to the living environ- ment and lack of physiological activities. The process was benign and could be alleviated ; and the features were genetically inherited.

关 键 词：C57BL/6J小鼠 脱毛 脱毛特征 皮肤病理 精神压力 

分 类 号：R-332[医药卫生]