石家庄地区体检人群非酒精性脂肪性肝病患病情况及危险因素分析  

Prevalence and risk factors of nonalcoholic fatty liver disease among physical examination population in Shijiazhuang area

作　　者：李静[1] 周利霞[1] 王俊明[2] 帖彦清[1] 翟俊轻[2] 姚敏[3] 

机构地区：[1]河北省人民医院检验科,石家庄050051 [2]河北省人民医院体检中心,石家庄050051 [3]河北医科大学生物化学与分子生物学研究室,石家庄050017

出　　处：《第二军医大学学报》2012年第8期879-884,共6页Academic Journal of Second Military Medical University

基　　金：河北省医学科学研究重点指令性项目(20100001)~~

摘　　要：目的分析石家庄地区体检人群非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的患病情况及其危险因素,为NAFLD的防治提供依据。方法收集2010年1月至12月在河北省人民医院体检中心和石家庄市河东社区卫生服务中心健康体检的体检人员资料,抽取所在单位或社区为石家庄市且居住5年以上、资料完整的健康查体者,共20 922名。统计该人群中NAFLD的患病率,并对其可能的相关危险因素进行单因素及多因素分析。结果目标人群中NAFLD患病率为19.18%(4 013/20 922),男性的总体患病率明显高于女性[23.40%(2 558/10 930)vs 14.56%(1 455/9 992),P<0.001],且存在明显的年龄差异;多因素logistic回归分析显示尿酸(UA)、收缩压(SBP)、体质量指数(BMI)、空腹血糖(FBG)和三酰甘油(TG)是NAFLD的独立危险因素,且其相对危险度依次升高。结论石家庄地区体检人群NAFLD的患病率较高,NAFLD的发生与TG、FBG、BMI、SBP和UA密切相关。Objective To investigate the prevalence of nonalcoholic fatty liver disease（NAFLD） and its risk factors in physical examination population of Shijiazhuang area,so as to provide evidence for prevention and treatment of NAFLD.Methods The medical examination results（January to December in 2010） were obtained from the physical examination center of Hebei Provincial People’s Hospital and Health Service Center of Hedong Community,Shijiazhuang.A total of 20 922 subjects who lived for more than 5 years in Shijiazhuang with complete data were selected for analysis.The prevalence and risk factors of NAFLD in this population were analyzed by univariate and multivariate analysis.Results The prevalence of NAFLD in the present group was 19.18%（4 013/20 922）,with that in males being significantly higher than that in females（23.40%[2 558/10 930] vs 14.56%[1 455/9 992],P〈0.001）,and there was significant age difference.Multiple logistic regression analysis demonstrated that uric acid（UA）,systolic blood pressure（SBP）,body mass index（BMI）,fasting blood glucose（FBG） and triglyceride（TG） were independent risk factors of NAFLD,and their relative risks increased in order.Conclusion The physical examination population in Shijiazhuang area has a high prevalence of NAFLD.The prevalence of NAFLD is closely associated with TG,FBG,BMI,SBP and UA.

关 键 词：非酒精性脂肪性肝病 患病率 危险因素 

分 类 号：R575.5[医药卫生—消化系统]