依达拉奉联合益肾定眩汤治疗急性后循环脑梗死32例临床报道  

Treatment of posterior circulation infarction by Edaravone and Yishen Dingxuan decoction

作　　者：张辰浩[1] 刘祖发[1] 王珺[1] 仝朝桢[1] 李依洁[1] 

机构地区：[1]中国中医科学院望京医院急诊科,北京100102

出　　处：《中华神经医学杂志》2012年第8期835-837,共3页Chinese Journal of Neuromedicine

摘　　要：目的观察依达拉奉联合益肾定眩汤治疗急性后循环脑梗死的临床疗效。方法选择自2010年1月至2011年6月望京医院收治的急性后循环脑梗死患者63例，按随机数字表法分为治疗组（32例）和对照组（31例）。治疗组予依达拉奉静脉输注联合自拟方益肾定眩汤（天麻、钩藤、川芎、鸡血藤、白术、泽泻、半夏、山萸肉、黄芪、枸杞、何首乌等组成）口服，对照组予依达拉奉联合疏血通静脉输注。2组患者均在治疗前和治疗14d后应用美国国立卫生研究院神经功能缺损评分量表mmSS）评分，并以评分改善（NmSS评分减少）程度作为疗效评价指标。结果治疗14d后治疗组NmSS评分（4．564±1．350）与对照组（7．976±1．830）比较差异有统计学意义（t=6．587，p=-0．021）。秩和检验发现疗效等级分布在2组间比较差异有统计学意义（Z=-2．338，P=0．019），进一步经平均秩次（治疗组26．89，对照组37．27）判断治疗组疗效优于对照组。结论应用依达拉奉联合益肾定眩汤治疗急性后循环脑梗死具有较好疗效。Objective To observe the treatment efficacy of Edaravone and Yishen Dingxuan decoction on patients with posterior circulation infarction. Methods Sixty-three patients with posterior circulation infarction, admitted to our hospital from January 2010 to June 2011, were randomly divided into treatment group （n=32） and control group （n=31）; treatment group was treated by Edaravone （intravenous infusion） and Yishen Dingxuan decoction （per os）, and Yishen Dingxuan decoction was composed of Tianma, Gouteng, Chuanxiong, Jixueteng, Baizhu, Zexie, Banxia, Shanyurou, Huangqi, Gouqi and Heshouwu. Control group was treated by edaravone （intravenous infusion） and Shuxuetong. National Institutes of Health Stroke Scale （NIHSS） was performed before and 14 d after the treatment; the decrement of the scores （the symptom improvement degree） was used as index to evaluate the efficacy. Results The NIHSS scores in the treatment group （4.564±1.350） were significantly different as compared with those in the control group （[7.976±1.830], t=6.587, P=-0.021）. Rank-sum test indicated that grade distribution of the efficacy between the 2 groups was significantly different （Z=-2.338, P=-0.019）, and mean rank test further proved that the treatment efficacy in treatment group （26.89） was better than that in the control group （37.27） Conclusion The treatment efficacy of Edaravone and Yishen Dingxuan decoction in patients with posterior circulation infarction is good.

关 键 词：依达拉奉 益肾定眩汤 脑梗死 后循环 

分 类 号：R743.3[医药卫生—神经病学与精神病学]